In this thesis I have dealt with the population genetic processes of
mockingbirds in the Galápagos Islands ( Mimus ) in relation to the limited
island area, from the perspective of two types of immune genes and the
genome-wide approach. The thesis starts with an introduction to
population genetic concepts relevant to conservation genetics followed by
description of immune genes: the major histocompatibility complex
(MHC) and the Toll-like receptors (TLR). In the final part of the
introduction, I address how genetic drift, selection and inbreeding shape
genome-wide genetic patterns in small populations. The introduction is
followed by four chapters, beginning with an examination of MHCII
polymorphism in populations of mockingbirds in the Galápagos Islands.
The study of the relationship between MHCII and the abundance of
ectoparasites is the content of the second chapter. The third chapter shows
how polymorphism of TLRs is shaped by interaction of genetic drift and
natural selection. The last chapter deals with the effects of limited island
size on inbreeding and genetic load, supported by inferences of the past
demography of mockingbirds. The thesis concludes with a summary of
the results and their potential implications in the field of conservation
genetics.
Anotace v angličtině
In this thesis I have dealt with the population genetic processes of
mockingbirds in the Galápagos Islands ( Mimus ) in relation to the limited
island area, from the perspective of two types of immune genes and the
genome-wide approach. The thesis starts with an introduction to
population genetic concepts relevant to conservation genetics followed by
description of immune genes: the major histocompatibility complex
(MHC) and the Toll-like receptors (TLR). In the final part of the
introduction, I address how genetic drift, selection and inbreeding shape
genome-wide genetic patterns in small populations. The introduction is
followed by four chapters, beginning with an examination of MHCII
polymorphism in populations of mockingbirds in the Galápagos Islands.
The study of the relationship between MHCII and the abundance of
ectoparasites is the content of the second chapter. The third chapter shows
how polymorphism of TLRs is shaped by interaction of genetic drift and
natural selection. The last chapter deals with the effects of limited island
size on inbreeding and genetic load, supported by inferences of the past
demography of mockingbirds. The thesis concludes with a summary of
the results and their potential implications in the field of conservation
genetics.
Klíčová slova
population genetics, birds, inbreeding, genetic drift, immunogenetics, conservation, MHC, TLR, major histocompatibility complex, Toll-like receptors, genome, genetic load, extinction, effective population size, island size
Klíčová slova v angličtině
population genetics, birds, inbreeding, genetic drift, immunogenetics, conservation, MHC, TLR, major histocompatibility complex, Toll-like receptors, genome, genetic load, extinction, effective population size, island size
Rozsah průvodní práce
244 s
Jazyk
AN
Anotace
In this thesis I have dealt with the population genetic processes of
mockingbirds in the Galápagos Islands ( Mimus ) in relation to the limited
island area, from the perspective of two types of immune genes and the
genome-wide approach. The thesis starts with an introduction to
population genetic concepts relevant to conservation genetics followed by
description of immune genes: the major histocompatibility complex
(MHC) and the Toll-like receptors (TLR). In the final part of the
introduction, I address how genetic drift, selection and inbreeding shape
genome-wide genetic patterns in small populations. The introduction is
followed by four chapters, beginning with an examination of MHCII
polymorphism in populations of mockingbirds in the Galápagos Islands.
The study of the relationship between MHCII and the abundance of
ectoparasites is the content of the second chapter. The third chapter shows
how polymorphism of TLRs is shaped by interaction of genetic drift and
natural selection. The last chapter deals with the effects of limited island
size on inbreeding and genetic load, supported by inferences of the past
demography of mockingbirds. The thesis concludes with a summary of
the results and their potential implications in the field of conservation
genetics.
Anotace v angličtině
In this thesis I have dealt with the population genetic processes of
mockingbirds in the Galápagos Islands ( Mimus ) in relation to the limited
island area, from the perspective of two types of immune genes and the
genome-wide approach. The thesis starts with an introduction to
population genetic concepts relevant to conservation genetics followed by
description of immune genes: the major histocompatibility complex
(MHC) and the Toll-like receptors (TLR). In the final part of the
introduction, I address how genetic drift, selection and inbreeding shape
genome-wide genetic patterns in small populations. The introduction is
followed by four chapters, beginning with an examination of MHCII
polymorphism in populations of mockingbirds in the Galápagos Islands.
The study of the relationship between MHCII and the abundance of
ectoparasites is the content of the second chapter. The third chapter shows
how polymorphism of TLRs is shaped by interaction of genetic drift and
natural selection. The last chapter deals with the effects of limited island
size on inbreeding and genetic load, supported by inferences of the past
demography of mockingbirds. The thesis concludes with a summary of
the results and their potential implications in the field of conservation
genetics.
Klíčová slova
population genetics, birds, inbreeding, genetic drift, immunogenetics, conservation, MHC, TLR, major histocompatibility complex, Toll-like receptors, genome, genetic load, extinction, effective population size, island size
Klíčová slova v angličtině
population genetics, birds, inbreeding, genetic drift, immunogenetics, conservation, MHC, TLR, major histocompatibility complex, Toll-like receptors, genome, genetic load, extinction, effective population size, island size
Zásady pro vypracování
-
Zásady pro vypracování
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Seznam doporučené literatury
-
Seznam doporučené literatury
-
Přílohy volně vložené
-
Přílohy vázané v práci
-
Převzato z knihovny
Ne
Plný text práce
Přílohy
Posudek(y) oponenta
Hodnocení vedoucího
Záznam průběhu obhajoby
Student přednesl ve 30 minutách svou prezentaci.
Školitel Štefka pochválil školence ve svém posudku.
Oponentka R. Reifová přednesla svůj posudek a padlo několik dotazů, např. jaké nejnovější metody by šly využít pro pro zpracování dat publikovaných v časopise Molecular Ecology? Jaké jsou disperzní schopnosti studovaného druhu.
Oponent O. Mikula přečetl svůj posudek s několika dotazy zaměřenými na metodiku a zpracování dat.
Dotazy z komise, např. jak ochranářsky pomocí populacím dozdců, jaký je vztah MHC a ektoparazitů atd.
Všichni členové komise byli přítomni: prof. Zrzavý, doc. Fucha, Dr.Robovský, Dr. Piálek, Dr. Reifová, prof. Šumbera, doc. Munclinger, doc. Říčan a Dr. Mikula