ATP synthase dimers have previously been identified to be major determinants of mitochondrial cristae ultrastructure. In order to determine the role of these dimers in the organellar architecture of Trypanosoma brucei, we performed a functional screen that identified a single T. brucei ATP synthase subunit that, upon depletion, destabilizes primarily dimers of the enzyme without disrupting the singular functional unit.
Anotace v angličtině
ATP synthase dimers have previously been identified to be major determinants of mitochondrial cristae ultrastructure. In order to determine the role of these dimers in the organellar architecture of Trypanosoma brucei, we performed a functional screen that identified a single T. brucei ATP synthase subunit that, upon depletion, destabilizes primarily dimers of the enzyme without disrupting the singular functional unit.
Klíčová slova
ATP synthase, Trypanosoma brucei, mitochondria
Klíčová slova v angličtině
ATP synthase, Trypanosoma brucei, mitochondria
Rozsah průvodní práce
70 p.
Jazyk
AN
Anotace
ATP synthase dimers have previously been identified to be major determinants of mitochondrial cristae ultrastructure. In order to determine the role of these dimers in the organellar architecture of Trypanosoma brucei, we performed a functional screen that identified a single T. brucei ATP synthase subunit that, upon depletion, destabilizes primarily dimers of the enzyme without disrupting the singular functional unit.
Anotace v angličtině
ATP synthase dimers have previously been identified to be major determinants of mitochondrial cristae ultrastructure. In order to determine the role of these dimers in the organellar architecture of Trypanosoma brucei, we performed a functional screen that identified a single T. brucei ATP synthase subunit that, upon depletion, destabilizes primarily dimers of the enzyme without disrupting the singular functional unit.