Lyme borreliosis is a disease caused by infection of selected members of the Borrelia burgdorferi sensu lato complex, a genus that keeps growing. With time, more and more members of this complex were identified as pathogenic for humans. This work aims to detect the spectrum of Borrelia spirochetes present in samples of Czech patients diagnosed with Lyme disease. Analysis will be used to suggest a tendency between the presence of the spirochetes' DNA found and the diagnosis of the patients.
Anotace v angličtině
Lyme borreliosis is a disease caused by infection of selected members of the Borrelia burgdorferi sensu lato complex, a genus that keeps growing. With time, more and more members of this complex were identified as pathogenic for humans. This work aims to detect the spectrum of Borrelia spirochetes present in samples of Czech patients diagnosed with Lyme disease. Analysis will be used to suggest a tendency between the presence of the spirochetes' DNA found and the diagnosis of the patients.
Klíčová slova
Lyme borreliosis, B. burgdorferi, B. miyamotoi, infection, Czech Republic, patients
Klíčová slova v angličtině
Lyme borreliosis, B. burgdorferi, B. miyamotoi, infection, Czech Republic, patients
Rozsah průvodní práce
46p. (81,219 characters)
Jazyk
AN
Anotace
Lyme borreliosis is a disease caused by infection of selected members of the Borrelia burgdorferi sensu lato complex, a genus that keeps growing. With time, more and more members of this complex were identified as pathogenic for humans. This work aims to detect the spectrum of Borrelia spirochetes present in samples of Czech patients diagnosed with Lyme disease. Analysis will be used to suggest a tendency between the presence of the spirochetes' DNA found and the diagnosis of the patients.
Anotace v angličtině
Lyme borreliosis is a disease caused by infection of selected members of the Borrelia burgdorferi sensu lato complex, a genus that keeps growing. With time, more and more members of this complex were identified as pathogenic for humans. This work aims to detect the spectrum of Borrelia spirochetes present in samples of Czech patients diagnosed with Lyme disease. Analysis will be used to suggest a tendency between the presence of the spirochetes' DNA found and the diagnosis of the patients.
Klíčová slova
Lyme borreliosis, B. burgdorferi, B. miyamotoi, infection, Czech Republic, patients
Klíčová slova v angličtině
Lyme borreliosis, B. burgdorferi, B. miyamotoi, infection, Czech Republic, patients
Zásady pro vypracování
-
Zásady pro vypracování
-
Seznam doporučené literatury
-
Seznam doporučené literatury
-
Přílohy volně vložené
1 table
Přílohy vázané v práci
ilustrace, mapy, grafy, tabulky
Převzato z knihovny
Ne
Plný text práce
Přílohy
Posudek(y) oponenta
Hodnocení vedoucího
Záznam průběhu obhajoby
Defence was hybrid, the student was present in person, the members of the commission were present in person or connected via MS Teams.
Prof. Grubhoffer welcomed the student and the commission.
The student presented her work „Detection of Lyme disease spirochetes and Borrelia miyamotoi in samples of Czech patients.“, - introduction to the topic, methods, results and summary.
Supervisor Dr. Rudenko presented her review.
Dr. Štěrba presented prof. Lloyd´s opponent review.
Student answered opponent´s questions on why Bbss is considered to have primarily arthritic symptoms, gender differences in Bbss infections in the US and Europe in the studied samples, why the studied samples were classified as problematic, why the presence of human DNA is problematic in the samples, primer specificity.
Student answered questions of the members of the commission:
Dr. Rego – how many patient samples for brain analysis, how many positive samples