This thesis examines Orai 1 mutants in cancer using chemichulation detection. It studies human-specific mutations and compares them to Drosophila melanogaster mutations. Pymol is used to visualize structural variations. The research aims to understand the molecular mechanisms of Orai 1 in cancer, potentially guiding the development of targeted cancer therapies.The objective of this study involves employing PyMOL, along with pertinent references, to explore
the chemiluminescence detection mechanism of membranes featuring the H134A+R91C mutation and the R91C mutation in humans. This investigation extends to a comparative analysis with the
closed-channel 4HKS(K163W) mutation observed in Drosophila melanogaster, which shares similarities with the R91W mutation in humans. Additionally, the study encompasses the open-
channel 6BBF (H206A) mutation in Drosophila melanogaster, akin to the H134A+R91C mutation in humans. Through these analyses, a deeper understanding of the chemiluminescence properties of these mutations across species can be gained.
Anotace v angličtině
The objective of this study involves employing PyMOL, along with pertinent references, to explore
the chemiluminescence detection mechanism of membranes featuring the H134A+R91C mutation and the R91C mutation in humans. This investigation extends to a comparative analysis with the
closed-channel 4HKS(K163W) mutation observed in Drosophila melanogaster, which shares similarities with the R91W mutation in humans. Additionally, the study encompasses the open-
channel 6BBF (H206A) mutation in Drosophila melanogaster, akin to the H134A+R91C mutation in humans. Through these analyses, a deeper understanding of the chemiluminescence properties of these mutations across species can be gained.
Klíčová slova
open-channel 6BBF (H206A) similar to H134A+R91C mutation in humans, closed-channel 4HKS(K163W) mutation similar to R91W mutation in humans
Klíčová slova v angličtině
open-channel 6BBF (H206A) similar to H134A+R91C mutation in humans, closed-channel 4HKS(K163W) mutation similar to R91W mutation in humans
Rozsah průvodní práce
57pp
Jazyk
AN
Anotace
This thesis examines Orai 1 mutants in cancer using chemichulation detection. It studies human-specific mutations and compares them to Drosophila melanogaster mutations. Pymol is used to visualize structural variations. The research aims to understand the molecular mechanisms of Orai 1 in cancer, potentially guiding the development of targeted cancer therapies.The objective of this study involves employing PyMOL, along with pertinent references, to explore
the chemiluminescence detection mechanism of membranes featuring the H134A+R91C mutation and the R91C mutation in humans. This investigation extends to a comparative analysis with the
closed-channel 4HKS(K163W) mutation observed in Drosophila melanogaster, which shares similarities with the R91W mutation in humans. Additionally, the study encompasses the open-
channel 6BBF (H206A) mutation in Drosophila melanogaster, akin to the H134A+R91C mutation in humans. Through these analyses, a deeper understanding of the chemiluminescence properties of these mutations across species can be gained.
Anotace v angličtině
The objective of this study involves employing PyMOL, along with pertinent references, to explore
the chemiluminescence detection mechanism of membranes featuring the H134A+R91C mutation and the R91C mutation in humans. This investigation extends to a comparative analysis with the
closed-channel 4HKS(K163W) mutation observed in Drosophila melanogaster, which shares similarities with the R91W mutation in humans. Additionally, the study encompasses the open-
channel 6BBF (H206A) mutation in Drosophila melanogaster, akin to the H134A+R91C mutation in humans. Through these analyses, a deeper understanding of the chemiluminescence properties of these mutations across species can be gained.
Klíčová slova
open-channel 6BBF (H206A) similar to H134A+R91C mutation in humans, closed-channel 4HKS(K163W) mutation similar to R91W mutation in humans
Klíčová slova v angličtině
open-channel 6BBF (H206A) similar to H134A+R91C mutation in humans, closed-channel 4HKS(K163W) mutation similar to R91W mutation in humans
Zásady pro vypracování
-
Zásady pro vypracování
-
Seznam doporučené literatury
-
Seznam doporučené literatury
-
Přílohy volně vložené
-
Přílohy vázané v práci
-
Převzato z knihovny
Ne
Plný text práce
Přílohy
Posudek(y) oponenta
Hodnocení vedoucího
Záznam průběhu obhajoby
The student presented her work.
She little exceeded the time given for the presentation.
The reviews have been read, and students address them briefly.