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Lecturer(s)
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Prášil Ondřej, prof. RNDr. Ph.D.
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Course content
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Students are provided with presentations from lectures and pdfs of textbooks on Moodle.
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Learning activities and teaching methods
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Monologic (reading, lecture, briefing)
- Class attendance
- 55 hours per semester
- Preparation for exam
- 45 hours per semester
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Learning outcomes
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Current research in bioenergetics. Transformation of energy in living organisms: overview, thermodynamic description. Overview of high energy compounds. Examples of mechanisms of energy conservation on the level of substrate. Biomembranes: lipids, proteins and their interactions. Mechanisms of membrane transport. Transporters, ion chanels, ionophores. Membrane transpoert ATPases. Enzymes, prosthetic groups and electron transporters in bioenergetically important redox reactions. Membrane bound electron transport chains. Methods how to study the electron transport chains. Artificial donors and acceptors. Coupling of redox reactions with the generation of proton gradient. Mitochondrial respiration and oxidative phosphorylation. Aerobic respiration in chemoorganotrophic and chemolithotrophic bacteria. Anaerobic respiration. Regulative mechanisms in facultativ anaerobs. Bacteriorhodopsin photosynthesis. Anoxygenic and oxygenic photosynthesis dependent on (bacterio) chlorophyll, cooperation of photosystems in oxygenic photosynthesis. Carbon fixation. Mutual metabolic cooperation of mitochondria, chloroplasts and cytoplasm. Mechanochemical energy transformation. Thermogenesisi in brown fat tissuei. Bioluminiscence. Bioenergetics of natrium ion. Evolution of bioenergetic processes. Bioenergetics and cycles of biogenic compounds in nature.
The graduate has detailed knowledge of bioenergetic processes. He / she is able to quantitatively describe and solve basic bioenergy processes.
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Prerequisites
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Basic knowledge of Biochemistry and Physical Chemistry (thermodynamics), elementary Mathematics
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Assessment methods and criteria
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Combined exam
Before the exam, the student must elaborate the examples discussed in the exercises.
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Recommended literature
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D.G.Nicholls, S.J.Ferguson: Bioenergetics 3, Academic Press, 2001, ISBN 0-12-518121-3.
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R.E.Blankenship: Molecular Mechanisms of Photosynthesis, Blackwell, 2002, ISBN 0-632-04321-0.
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