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Lecturer(s)
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Kaščáková Barbora, Mgr. Ph.D.
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Rozbeský Daniel, Mgr. Ph.D.
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Macůrek Libor, MUDr. Ph.D.
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Huranová Martina, Mgr. Ph.D.
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Vyklický Ladislav, prof. MUDr. DrSc.
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Macůrková Marie, Mgr. Ph.D.
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Sedláček Radislav, XXX Dr. rer. nat.
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Mráček Tomáš, RNDr. Ph.D.
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Fencková Michaela, Mgr. Ph.D.
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Janoštiak Radislav, RNDr. Ph.D.
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Ellederová Zdeňka, Ing. Ph.D.
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Course content
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Content of lectures: Introduction into research of disease mechanisms Protein structure: crystallography and structural modelling of disease variants CryoEM and Protein-protein interactions NMDA Receptors in Health and Disease Drosophila as a model for human disease C.elegans as a model for development and cell signalling in health and disease Primary mitochondrial disorders - from diagnostics to molecular mechanisms (biochemist's perspective) Primary Cilia in Health and Disease DNA repair and its impact on human health Large Animal Models as Translational Platforms for Cell and Gene Therapy Patient-derived 3D organoids and organ-on-chip technology in molecular oncology Czech Centre for Phenogenomics and genetically modified mouse models of disease Content of tutorials/seminar: For each seminar, students will prepare a presentation of a scientific article that covers one of the lectures´ topics and that will be discussed in the class.
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Learning activities and teaching methods
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- Semestral paper
- 20 hours per semester
- Preparation for classes
- 25 hours per semester
- Preparation for exam
- 30 hours per semester
- Class attendance
- 67 hours per semester
- Preparation for credit
- 8 hours per semester
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Learning outcomes
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This course acquaints students with state-of-the-art experimental genetic and computational approaches in translational research of human disease. The approaches will be presented by experts in the field who will include examples of their current research. Each lecture will be coupled with a seminar where the students will process up-todate literature and discuss it with the rest of the class. Finally, the theoretical knowledge will be complemented with an excursion to the laboratories of the leading research institutes of the Czech Academy of Sciences (IMG, BIOCEV, IPHYS). This concept will broaden the students' perspectives for choosing research interest for possible further exploration during their Master studies, and reinforce their critical thinking and problem-solving.
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Prerequisites
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Genetics, Molecular Biology (KBM/250 or equivalent course from former university).
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Assessment methods and criteria
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unspecified
Requirements on student: credit: attendance at practicals and seminars (max. 3 absences), presentation 1x semester exam: written (50 %)
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Recommended literature
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Lecturers will provide students with scientific articles that the students will present at the seminars.
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William B. Coleman and Gregory J. Tsongalis: Molecular pathology, 2nd edition, 2018.
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