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Lecturer(s)
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Course content
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1. Prevalence and curability of cancer 2. Main hallmarks of cancer. The development of opinions on origin of tumors. Malignant and benign tumors 3. Biology, biochemistry, and bioenergetics of tumors 4. Therapeutic approaches and their limits, surgery, chemotherapy, radiotherapy 5. The possibilities of an antitumor attack on the level of innate and adaptive immunity. Advantages and disadvantages of both ways. Studies of prof. Cui 6. Cancer therapy based on stimulation of innate immunity, PRR ligands, realization 7. Tumors and complement 8. Participation of adaptive immunity, mechanisms of escape and defence against immune attack 9. Checkpoints 10. Immunotherapy of cancer, the use of cytokines 11. Immunotherapy of cancer, peptide and DNA vaccines 12. Oncolytic viruses 13. Therapy based on the use of dendritic cells, mol. biol. methods 14. Biological therapy 15. Methods of a preclinical study of cancer immunotherapy 16. Complex cancer immunotherapy and immunometabolic therapy
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Learning activities and teaching methods
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unspecified
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Learning outcomes
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Students become acquainted with the tumor diseases, biology, biochemistry and immunology of tumors and possibilities of therapeutic intervention focused on cancer immunotherapy.
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Prerequisites
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KME/216
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Assessment methods and criteria
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unspecified
Answer sufficiently to at least 4 out of 6 questions
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Recommended literature
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Dunn GP et al. 2002: Cancer immunoediting: from immunosurveillance to tumor escape. Nat Immunol 3: 991-998..
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Finke J. H., Bukowski R. M. 2004: Cancer immunotherapy at the crossroads. How tumors evade immunity and what can be done. Humana Press, Totowa, New Jersey, 386 pp..
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Male D., Brostoff J., Roth D.B., Roitt I. 2006: Immunology. Seventh Edition. Elsevier, Canada, 552 pp..
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Marabelle et al. 2014: Intratumoral immunization: A new paradigm for cancer therapy, Clinical Cancer Research, vol. 20, no. 7, pp. 1747-1756..
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McKinnell R.G., Parchment R.E., Perantoni A.O., Pierce G.B. 2000: The biological basis of cancer. Cambridge University Press, Cambridge, United Kingdom, 373 pp..
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