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Lecturer(s)
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Lieskovská Jaroslava, doc. Mgr. Ph.D.
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Course content
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1. General virology- the composition of virions, structure, classification of viruses based on types of viral nucleic acids, molecular basis of the replication and expression of viral genome 2. Pathogenesis of viral infections; the virus entry, replication, transmission within host organism, types of viral infection-acute versus persistent. The effects of viral infection on cellular level. Vaccination and immune reaction to viral infection. Laboratory technics used in virus diagnostics. 3. Poxviridae - variola virus, vaccinia virus, molluscum contagiosum virus (characterization of the family, pathogenesis, clinical picture of diseases). 4. Herpesviridae - herpes simplex 1 and 2, varicella-zoster virus, cytomegalovirus, Epstein Barr virus, human herpes viruses 6, 7, 8 (characterization, pathogenesis, symptoms of diseases). 5. Papillomaviridae and polyomaviridae - the etiologic agents of benign and oncogenic tumors; the mechanism of virus induced cellular transformation. 6. Rhabdoviridae - rabies virus; Paramyxoviridae-mumps virus, measles virus (characterization of the family and pathogenesis). 7. Orthomyxoviridae - influenza virus (characterization of the family and pathogenesis). 8. Filoviridae - Ebola virus and other viruses causing hemoragic fever (characterization of the family, pathogenesis and epidemiology). 9. Picornaviridae - polio virus, human enteroviruses; Reoviridae - rota virus (characterization of the families and pathogenesis). 10. Flaviviridae and other arboviruses (characterization of the family, transmission and pathogenesis). 11. Hepadnaviridae and other viruses causing viral hepatitis - hepatitis virus B, C, A (characterization of the family, pathogenesis and epidemiology). 12. Retroviridae - virus HIV (characterization of the family, pathogenesis of AIDS, epidemiology and anti-retroviral therapy).
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Learning activities and teaching methods
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Monologic (reading, lecture, briefing)
- Class attendance
- 26 hours per semester
- Preparation for classes
- 4 hours per semester
- Preparation for exam
- 50 hours per semester
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Learning outcomes
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The diversity of viruses exceeds that of all other living organisms combined. This course will introduce students i) genome organization and replication strategy of viruses ii) an overview of significant families of human viruses and their pathogenesis iii) strategies to prevent or treat virus infections.
Students understand the basis of virus structure, genome organization and replication strategies. Students gain overview of various families of viruses, the information about their transmission and pathogenesis. Students get familiar with common virus detection methods.
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Prerequisites
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no special prerequisites
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Assessment methods and criteria
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Written examination
To show knowledge and understanding of content of lectures (to reach 70 % in written test; oral exam if needed)
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Recommended literature
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Cann A.J. Principles of Molecular Virology, 4th edition, Elsevier 2005, 352 p.,. 2005.
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Digard, P., Nash, A.A., Randall, R.E. Molecular Pathogenesis of Virus Infections by Cambridge University Press, Issue 64, 2005. 2005.
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Flint, S.J., Enquist, L.W., Racaniello, V.R., Skalka. Principles of Virology, Volume I: Molecular Biology, 3rd Edition, 2009.. 2009.
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