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Lecturer(s)
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Chmelař Jindřich, doc. RNDr. Ph.D.
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Course content
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Content of lectures: 1. What is biomedicine? Introduction to the subject. Where medicine and biology meet? The history of biomedicine, important milestones and discoveries 2. Main areas and trends in biomedical research, interconnection of basic research with the development of new biotechnologies, therapies and diagnostic methods, clinical research, biomedical industry and employment possibilities. 3. Fundamentals of human body functions - anatomy, physiology, homeostasis x pathology 4. Basics of cell biology and genetics of human, epigenetic regulation, genetic diseases 5. Overview of human biochemistry, metabolic processes - respiration, catabolism, anabolism, biomacromolecules, related pathologies 6. Basics of human molecular biology - central dogma, cell signalling 7. Immune system I - innate immunity, inflammation, cellular and humoral immunity, cytokines 8. Immune system II - acquired immunity, antigens, allergies 9. In vitro and in vivo models of human diseases I - respiratory, digestive and excretory system 10. In vitro and in vivo models of human diseases II - bones, muscles and skin 11. In vitro and in vivo models of human diseases III - endocrine, nervous, immune and circulatory system 12. Civilization diseases, metabolic syndrome, cancer, cardiovascular diseases, infectious diseases 13. Project and experiment in experimental biomedicine - project design, ethical and legal aspects of clinical and biomedical research Content of practicals: Practicals will be held in the form of "journal club". Students will choose research paper from the list and prepare a presentation, in which they will present the topic, methodics, results and conclusion of the study. The main goal of practicals is to teach students to work with scientific literature and find relevant information. The requirement for credit from practicals is absolved presentation and submitted semestral work on given topic.
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Learning activities and teaching methods
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Monologic (reading, lecture, briefing), Work with text (with textbook, with book), Projection, Individual preparation for exam
- Class attendance
- 56 hours per semester
- Preparation for credit
- 40 hours per semester
- Preparation for exam
- 30 hours per semester
- Preparation for classes
- 35 hours per semester
- Semestral paper
- 40 hours per semester
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Learning outcomes
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The main course objective is to initiate students into the broad research field of biomedicine, which involves not only wide range of interconnected research disciplines, but is one of the most developing and growing area of industry, focused on human health. This makes biomedicine very attractive and perspective field of study. Students will familiarize themselves with main areas and trends in biomedical research, basic principles of human body functioning at organismal, tissue, cellular, molecular and biochemical level. Chosen human pathological states or diseases will be used to show the interconnection among various biomedical disciplines. Ethical and legal aspects of biomedical and clinical research will be discussed. The course should prepare students for further, more specialized subjects and should enable them to think about individual biological processes in broader perspective.
Students know main areas and trends in biomedical research and development Studnets understand basic principles of human body functions at organismal, tissue, cellular, molecular and biochemical level.
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Prerequisites
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High school level of knowledge on the human biology.
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Assessment methods and criteria
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Written examination, Seminar work
Test at minimum 60% of points. Semestral work. Presentation of selected research article at practicals.
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Recommended literature
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Alberts, B., Bray, D., Lewis, J., Raff, M., Roberts, K., Watson, J.D. Molecular Biology of the Cell. Garland Publishing, Inc. NY, 1998. ISBN 0-8153-1620-8.
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Hořejší, V., Bartúňková, J. Základy imunologie. Prah Triton, 2009.
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Kindt TJ., Goldsby R.A., Osborne B.A. Kuby Immunology (6th ed.), W.H. Freeman and Copany, New York 2007, 574.
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Rokyta, R. a kol. Fyziologie. Praha, ISV, 359 s., 2000.
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Rokyta, R., Šťastný, F.:. Struktura a funkce lidského těla. Praha: Tigis. 2002.
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Silbernagl, S., Despopoulos, A. Atlas fyziologie člověka. Praha Grada, 2004.
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Vodrážka,Z. Biochemie, Academia Praha, 2007. 2007.
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