|
Lecturer(s)
|
-
Lieskovská Jaroslava, doc. Mgr. Ph.D.
-
Kopecký Jan, prof. RNDr. CSc.
|
|
Course content
|
- 1. Overview of basic function of adaptive and innate immunity, immune cells, regulation of immune system. - 2. Innate immunity characterization of pathogen associated molecular pattern (PAMPs) and danger associated molecular pattern (DAMPs) as a basic triggers of immune reaction. - 3. Receptors involved in recognition of PAMPs-their classification, structure and specificity (TLR, NLR, RLR, CLR), effector mechanisms of innate immunity -phagocytosis, other receptors on cells of innate immunity (scavanger and complement receptors). - 4. Receptors on T and B lymphocytes and their activation by antigen, class I and II MHC molecules, presentation of antigenic peptides, effector mechanism of acquired immunity. - 5. Classification and features of T lymphocytes, polarization of immune response. - 6. Signaling through immune system receptors - general principles of signal transduction. - 7. Signaling in innate immunity and inflammation. - 8. Antigen receptor signaling, cytokines receptors and their activation. - 9. Development of B and T lymphocytes, rearrangement of receptor genes. - 10. Adhesive molecules and recirculation of lymphocytes. - 11. Design of experiments for study of immune response to infection.
|
|
Learning activities and teaching methods
|
Monologic (reading, lecture, briefing)
- Preparation for exam
- 50 hours per semester
- Class attendance
- 26 hours per semester
- Preparation for classes
- 4 hours per semester
|
|
Learning outcomes
|
This course will introduce molecular mechanisms of innate and adaptive immunity. It will provide an essential grounding for the understanding of the complex cellular interactions of the immune response.
Student has overview of immune system properties. Student will learn how works the innate and adaptive immunity, how is the function of particular immune cells and how works the regulation of immune system.
|
|
Prerequisites
|
mandatory prerequisite - Immunology KME/2016
KME/216
|
|
Assessment methods and criteria
|
Oral examination
Short presentation (about 10 min) of a selected article with a relevant topic. Passing the exam with a score of at least 60%
|
|
Recommended literature
|
-
Abbas A.K., Lichtman A.H., Pillai S.: Cellular and Molecular Immunology (8th ed.), Elsevier 2015, 544..
-
Murphy K., Travers p., Walport M.: Janewayś imunology (7th ed.), Garland Science, Taylor & Francis Group, LLC, New York 2008, 887..
|