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Lecturer(s)
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Kopecký Jan, prof. RNDr. CSc.
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Chmelař Jindřich, doc. RNDr. Ph.D.
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Course content
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1. Immunity ? overview of the basic functions: the role of immune system, innate and adaptive immunity, regulation of the immune system. 2. Experimental systems in immunology. Cells and organs of the immune system: lymphocytes, mononuclear phagocytes, granulocytes, primary and secondary lymphoid organs, recirculation of lymphoid cells. 3. Antigens: chemical and biological properties, adjuvants, haptens, viral and bacterial antigens, mitogens,. Structure and function of immunoglobulins: antigenic determinants, on immunoglobulins, properties and function of immunoglobulin classes. 4. Antigen - antibody interaction: affinity avidity, immunological cross-reactivity. Immunochemical reaction. Monoclonal antibodies. 5. Organisation and expression of immunoglobulin genes.: development of antibody diversity. 6. Major histocompatibility complex: structure and function of MHC molecules. T-receptor: development of TCR diversity, MHC restriction, development of T cells. 7. Cytokines: structure and function of cytokines and their receptors. Development of humoral immune response: primary and secondary response, antigen presentation, role of cytokines,. 8. Cell-mediated immunity: T-cell cytotoxicity, antibody-dependent cell-mediated cytotoxicity, delayed type of hypersensitivity. Regulation of immunity, immunological tolerance. 9. The complement system: classical pathway, alternative and lectin pathway of complement activation, regulation. Hypersensitivity: immediate and delayed hypersensitivity, anaphylaxis, hypersensitivity from immune complexes. 10. Vaccines: inactivated, attenuated, subunit, recombinant, vector vaccines. Immune response to infection: viral, bacterial and parasitic infections. 11. Transplantation immunology: transplantation antigens, mechanisms of graft rejection, immunosuppression. Anti-cancer immunity: malignant transformation of cells, tumour antigens, tumour immunotherapy.
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Learning activities and teaching methods
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Monologic (reading, lecture, briefing)
- Class attendance
- 28 hours per semester
- Preparation for exam
- 40 hours per semester
- Preparation for classes
- 28 hours per semester
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Learning outcomes
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Students are introduced to the structure and function of immune system, natural and adaptive immunity and its regulation.
Students will gain the basic knowledge about the structure and function of immune system.
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Prerequisites
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Not specified
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Assessment methods and criteria
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Oral examination
The student must understand the immune system of mammals. He/she should know particular mechanisms of the immune response, ways of antigen recognition, generating diversity of antibodies and T cell receptor, regulation of the immune response. Students should be able to apply general knowledge of the immune system to immunity against infection or antitumor immunity. Student is asked several questions and must answer at least 70% of questions to at least 80%. Final grade is derived from partial results. The exam has two parts, each lecturer examines separatelly.
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Recommended literature
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Coico R., Sunshine G.: Imunology: a short course (6th ed.), John Wiley & Sons, Inc., Hobojem, New Persey 2009, 391.
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Kindt TJ., Goldsby R.A., Osborne B.A.: Kuby Immunology (6th ed.), W.H. Freeman and Copany, New York 2007, 574.
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B M Hannigan. Immunology. SCION PUBLISHING, 2009. ISBN 1904842569.
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