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Lecturer(s)
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Grubhoffer Libor, prof. RNDr. CSc.
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Course content
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- Chemical basics of molecular evolution and ontogeny of living organism - Nucleic Acids and nuclear proteins - Structural variety and metabolism of proteins - Plasma proteins, yolk proteins, and metal-binding proteins - Immunoproteins - Respiratory pigments - Peptide hormones - Toxic proteins and peptides - Muscle proteins and cytoskeleton - Extracellular structural and secretory proteins - Structure and metabolism of carbohydrates - Lipids - Sterols and steroids - Metabolic pathways; Oxidative metabolism - Secondary metabolites - Integrative biochemistry of living organisms
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Learning activities and teaching methods
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Monologic (reading, lecture, briefing), Work with text (with textbook, with book), Work with multi-media resources (texts, internet, IT technologies)
- Class attendance
- 26 hours per semester
- Semestral paper
- 25 hours per semester
- Preparation for exam
- 25 hours per semester
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Learning outcomes
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Developmental and comparative biochemistry addresses biochemical and molecular/cellular biological aspects of evolutionary history and ontogeny of living organisms. The use of model organisms {Escheria coli; parasitic unicellular eukaryots; parasitic metazoans (worms), caenorhabditis (free living worm); drosophila fly; autotrophic organisms/microorganisms, vertebrates/mammalians} and selected unique traits of structural and functional features of individual molecules or their pathways is a practical approach that makes such voluminous subject feasible and accessible. Following themes will be addressed: ? Chemical basics of molecular evolution and ontogeny of living organism ? Nucleic Acids and nuclear proteins ? Structural variety and metaabolism of proteins ? Plasma proteins, youlm proteins, and metaal-binding proteins ? Immunoproteins ? Repiratory pigments ? Peptide hormons ? Toxi proteins and peptides ? Muscle proteins and cytoskeleton ? Extracellular structural and secretory proteins ? Structure and metabolism of carbohydrates ? Lipids ? Sterols and steroids ? Metabolic pathways; Oxidative metabolism ? Secondary metabolites ? Integrative biochemistry of living organisms
Students wil gain knowledge in developmental and comaparative biochemistry.
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Prerequisites
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knowledge of biochemistry, cellular and molecular biology
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Assessment methods and criteria
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unspecified
Participation in lectures and passing a test.
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Recommended literature
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Bennet E.-M., Behn C., Bryant Ch. Comparative Biochemistry of Parasitic Helminths. Chapman & Hall, 1989..
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Klaus U. Comparative Animal Biochemistry. Springer Verlag, berlin, Heidelberg, New York, 1994.
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Marr J. J. & Mueller M. Biochemistry and Moleculraa Biology of Parasites. Academic Press, 1995.
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