Lecturer(s)
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Durchan Milan, RNDr. CSc.
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Course content
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Content of lectures: Molecules in universe. The role of bioelements in structures of organisms. Moleclar organisation of biological systems. Physics of water in its biological importance. Experimental methods of study of hydrogen bonds. Gibbs energy in molecular biology, basics of therodynamics. Electrostatic interactions. Spectroscopy of dimers. Weak chemical bonds in biological molecules. Forces determining the structure of nucleic acids. Hydrophobic effect and solvatation. Ionic interaction and S-S bonds in proteins. Peptidic bond and polypeptide chain. Conformation of proteins. Ramaendran's diagrams, potential function, structure prediction. Conformation of nucleic acids, bases, sugars, angles. DNA -B, A and Z forms.
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Learning activities and teaching methods
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Monologic (reading, lecture, briefing), Work with text (with textbook, with book), Demonstration, Projection, Individual preparation for exam, Excursion
- Field trip
- 3 hours per semester
- Preparation for classes
- 5 hours per semester
- Semestral paper
- 2 hours per semester
- Class attendance
- 28 hours per semester
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Learning outcomes
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Explain role of conformations and molecular interactions for structure and function of biological molecules.
Students intensify their secondary school knowledge of physics and interdisciplinary fields (biochemistry, photobiology,...).
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Prerequisites
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An introductory course in biophysics, which aim is to popularize the discipline.
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Assessment methods and criteria
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Oral examination, Seminar work
Student's own presentation on one of the proposed topics, discussion on this topic. Oral exam.
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Recommended literature
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Bruce Alberts: Základy buněčné biologie, Úvod do molekulární biologie buňky, Espero Publishing, Ústí nad Labem, 2001.
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J.David Rawn: Biochemistry, Neil Patterson Publishers, Burlington, N. Carolina, 1989.
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Pavel Hobza, Rudolf Zahradník: Mezimolekulové komplexy - Úloha van der Waalsových systému ve fyzikální chemii a v biodisciplinách, Academia, Praha 1988.
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Zdeněk Vodrážka: Fyzikální chemie pro biologické vědy, Academia, Praha 1982.
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