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Lecturer(s)
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Tůma Roman, prof. Mgr. Ph.D.
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Koník Peter, Mgr. Ph.D.
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Dyčka Filip, Mgr. Ph.D.
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Doležal Tomáš, doc. Mgr. Ph.D.
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Horák Aleš, Mgr. Ph.D.
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Nguyen Petr, RNDr. Ph.D.
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Gahurová Lenka, Mgr. Ph.D.
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Gahura Ondřej, Mgr. Ph.D.
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Sobotka Roman, prof. Ing. Ph.D.
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Jindra Marek, prof. RNDr. CSc.
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Moos Martin, Ing. Ph.D.
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Course content
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1. Genome architecture, evolution and variation 2. Next generation sequencing technologies, genomics and metagenomics 3. Gene expression regulation, epigenetics and epigenomics 4. RNA structure and function, transcriptomics 5. Protein structure and function, modern structural biology 6. Proteomics 7. Functional biochemistry and physiology, metabolomics and fluxomics 8. Cell signaling, cell-cell interaction, interorgan communication, development 9. Single-cell OMICs, spatial multi-OMICs, functional genomics, transcriptomics and proteomics in physiology and developmental biology 10. OMICs in microbiology and virology, metagenomics 11. Gene editing tools and genetic engineering Genetic engineering and synthetic biology
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Learning activities and teaching methods
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unspecified
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Learning outcomes
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The aim of the course is to introduce students to OMICs approaches and biotechnologies in both basic and applied biological and biomedical research and related technologies. It is only a basic overview of where and how these technologies can be used and a principal introduction to the methodologies. Associated with each approach and technology is selected knowledge of biological issues necessary to understand OMICs approaches and technologies that go beyond the knowledge of undergraduate molecular and cell biology. Students will later explore specific approaches and technologies in their particular specializations; the purpose of this introduction is simply to provide an overview that the technologies exist and what they are used for. Also linked to this course are "Seminars in Omics & Biotechnology", where selected scientists will present specific examples of applications of these technologies, as well as "Essays in Omics & Biotechnology", where students will develop a contemporary topic on an application of these technologies and present it to other students, ensuring that these rapidly evolving approaches are continually updated.
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Prerequisites
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unspecified
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Assessment methods and criteria
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unspecified
written exam (min. 50 %)
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Recommended literature
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Copies of lecture presentations with in-text comments.
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Current web links to relevant approaches and technologies.
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Journal "Genetic Engineering & Biotechnology News" - selected articles and collections on topics.
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