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Lecturer(s)
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Panicucci Zíková Alena, doc. RNDr. Ph.D.
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Doležal Tomáš, doc. Mgr. Ph.D.
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Sobotka Roman, prof. Ing. Ph.D.
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Bajgar Adam, Mgr. Ph.D.
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Moos Martin, Ing. Ph.D.
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Course content
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Topics: 1. Photosynthesis and plastid biology 2. Biotechnology and synthetic biology of photosynthetic organisms 3. Mitochondrial metabolism 4. Biology of Reactive Oxygen Species 5. Glycolysis and Pentose Phosphate Pathway 6. Lipid metabolism 7. Cancer metabolism and immunometabolism 8. Concepts of molecular integrative physiology, metabolites as signalling molecules 9. Aging cell, aging organism 10. Technologies - proteomics, metabolomics and fluxomics 11. Technologies - live metabolic sensors 12. Technologies - spatial multi-OMICs
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Learning activities and teaching methods
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unspecified
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Learning outcomes
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The aim of the course is to introduce modern molecular physiology and metabolism, which, thanks to new technologies (such as metabolomics and fluxomics), are beginning to complement other OMICs approaches in a wide range of biological applications. The course will introduce various topics in the physiology of unicellular organisms, plants and animals, including humans, and related biomedical problems in selected chapters. The aim is to introduce selected hot topics in modern molecular biochemistry and physiology and to demonstrate modern methodological approaches, not to cover the whole molecular physiology in a textbook fashion.
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Prerequisites
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unspecified
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Assessment methods and criteria
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unspecified
written exam (min. 50 %)
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Recommended literature
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Copies of lecture presentations with text comments.
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Lehninger Principles of Biochemistry (8th edition).
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2. Functional Biochemistry in Health and Disease (Newsholme and Leech, Willey 2010).
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