| Course title | Molecular immunology |
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| Course code | KME/087E |
| Organizational form of instruction | Lecture |
| Level of course | Master |
| Year of study | not specified |
| Frequency of the course | In academic years starting with an odd year (e.g. 2017/2018), in the summer semester. |
| Semester | Summer |
| Number of ECTS credits | 3 |
| Language of instruction | English |
| Status of course | Compulsory-optional |
| Form of instruction | Face-to-face |
| Work placements | This is not an internship |
| Recommended optional programme components | None |
| Course availability | The course is available to visiting students |
| Lecturer(s) |
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| Course content |
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1. Overview of basic function of adaptive and innate immunity, immune cells, regulation of immune system. 2. Innate immunity characterization of pathogen associated molecular pattern (PAMPs) and danger associated molecular pattern (DAMPs) as a basic triggers of immune reaction. 3. Receptors involved in recognition of PAMPs-their classification, structure and specificity (TLR, NLR, RLR, CLR), effector mechanisms of innate immunity -phagocytosis, other receptors on cells of innate immunity (scavanger and complement receptors). 4. Receptors on T and B lymphocytes and their activation by antigen, class I and II MHC molecules, presentation of antigenic peptides, effector mechanism of acquired immunity. 5. Classification and features of T lymphocytes, polarization of immune response. 6. Signaling through immune system receptors - general principles of signal transduction. 7. Signaling in innate immunity and inflammation. 8. Antigen receptor signaling, cytokines receptors and their activation. 9. Development of B and T lymphocytes, rearrangement of receptor genes. 10. Adhesive molecules and recirculation of lymphocytes. 11. Design of experiments for study of immune response to infection.
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| Learning activities and teaching methods |
Monologic (reading, lecture, briefing)
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| Learning outcomes |
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This course will introduce molecular mechanisms of innate and adaptive immunity. It will provide an essential grounding for the understanding of the complex cellular interactions of the immune response.
mandatory prerequisite - Immunology KME/2016 |
| Prerequisites |
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Basics of immunology.
KME/216 ----- or ----- KME/723 |
| Assessment methods and criteria |
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Oral examination
Short presentation (approx. 10 min) of selected paper with relevant topic. Passing the exam with a score of 60% |
| Recommended literature |
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| Study plans that include the course |
| Faculty | Study plan (Version) | Category of Branch/Specialization | Recommended semester |
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