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Lecturer(s)
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Chmelař Jindřich, doc. RNDr. Ph.D.
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Lieskovská Jaroslava, doc. Mgr. Ph.D.
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Langhansová Helena, RNDr. Ph.D.
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Bajgar Adam, doc. Mgr. et Mgr. Ph.D.
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Course content
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Content of tutorials/seminar: 1. Evolution of immune system 2. Development of the immune system during embryogenesis and childhood 3. B-cell development, mechanisms and genetic basis of antibody diversity 4. Antigens, superantigens, signaling pathways, and different types of immune cell activation and differentiation 5. Immunological memory in B and T cells 6. Principles of central and peripheral self-tolerance 7. Transplantation immunology and cancer immunology 8. Mucosal and skin immunity 9. Allergy and hypersensitivity 10. Immunodeficiencies 11. Infectious immunology and vaccines
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Learning activities and teaching methods
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unspecified
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Learning outcomes
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Course objectives: The Immunology II course aims to expand students' understanding of the principles underlying immunological processes. In the introductory course, students became familiar with the cells and molecules of the immune system, the course of the immune response, the fundamentals of innate and adaptive immunity, and the major types of immune reactions. In this follow-up course, students will gain deeper insight into the cellular and molecular mechanisms of these responses, as well as the evolution and ontogeny of the immune system and the molecular basis of the enormous diversity of antibodies and T-cell receptors. Special attention is given to immunological memory, self-tolerance, and the principles of immune disorders. The course also covers anti-infectious immunity and barrier immunity.
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Prerequisites
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Prerequisites, preconditions: Prerequisite: Basic knowledge of immunology equivalent to that covered in the course Immunology I. KME/216
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Assessment methods and criteria
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unspecified
Requirements on student: Test must be successfully finnished at least at 50%
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Recommended literature
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Abbas, A. K.; Lichtman, A. H.; Pillai, S.; Henrickson, S. E. Cellular and Molecular Immunology. 11th ed. Philadelphia: Elsevier, 2026. ISBN 978-0443283581..
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Hořejší, V.; Bartůňková, J.; Brdička, T.; Špíšek, R. Základy imunologie. 7., aktualizované vydání. Praha: Triton, 2024. ISBN 978-8076841819.
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Murphy, K.; Weaver, C. Janeway's Immunobiology. 10th ed. New York: W. W. Norton & Company, 2022. ISBN 978-0393884890..
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Owen, J. A.; Punt, J.; Stranford, S. A.; Jones, P. P. Kuby Immunology. 9th ed. New York: W. H. Freeman/Macmillan Learning, 2023. ISBN 978-1319114701..
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