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Lecturer(s)
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Štefka Jan, doc. RNDr. Ph.D.
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Vlček Jakub, RNDr. Ph.D.
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Course content
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Content of lectures: 1. What does microevolution mean? The start, the end and the rate of population genetic processes. 2. Genetic variability and microevolution. 3. Quantifying population diversity. 4. Models in population genetics - Wright-Fisher model. 5. Models in population genetics - Hardy-Weinberg equilibrium. 6. Models in population genetics - Multilocus equilibrium. 7. Population structure and genetic diversity. 8. Finite population size and its implications. 9. Gene flow, mutation and selection. 10. Gene flow, mutation and selection II. 11. When the theory fails - neutral evolution vs. Lewontin's paradox. 12. Genomic diversity and Lewontin's paradox. 13. Speciation genomics - mechanisms driving population diversity at the genomic level. Content of tutorials/seminar: Students will practice acquired knowledge using selected examples both by manual calculation and by PC computation. Students will prepare mini-projects aimed at population genetic analysis of a selected model or non-model biological species.
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Learning activities and teaching methods
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unspecified
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Learning outcomes
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Students will understand basic principles of origin and maintenance of population genetic diversity and their application in microevolutionary processes (speciation).
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Prerequisites
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Basic knowledge of genetics and the principles of heredity.
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Assessment methods and criteria
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unspecified
Pass a written test (at least 50% score) + successful presentation of a mini-project
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Recommended literature
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Hamilton M. B. (2009) Population genetics, 1st ed. Wiley - Blackwell, Chichester, West Sussex, UK..
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Presentations from lectures.
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Templeton, A. R. (2006) Population genetics and microevolutionary theory. Hoboken: Wiley-Liss.
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