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Lecturer(s)
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Carey Jannette Rita Lazar, Ph.D.
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Tůma Roman, prof. Mgr. Ph.D.
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Fessl Tomáš, Mgr. Ph.D.
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Course content
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1) Overview of basic protein structure and function, using ligand binding as focal point. 2) - 5) Selected readings of key papers (one per day) from primary research literature that follow the development of modern concepts of proteins as dynamic and thermodynamic entities. Each reading assignment will be accompanied by a few study questions that students shall prepare for oral group discussion on the following day.
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Learning activities and teaching methods
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unspecified
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Learning outcomes
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Students will acquire overview of theoretical principles and basics of running molecular dynamics simulations, and interpreting the results in the frame of protein structure, dynamics, and thermodynamics.
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Prerequisites
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UCH 643 Biochemistry II or equal.
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Assessment methods and criteria
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unspecified
Required attendance and active oral participation at all tutorials/seminars. Students are expected to apply knowledge of principles of protein structure and function gained in their prior coursework. Self-study of the subject is integral part of the course. Classes will meet for one week during June-July, two hours each day for five days = total 10 class hours plus 20 hours self-study and remote computer work
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Recommended literature
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Carey, J. Ligand-binding basics..
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one brief paper will be assigned for every class meeting..
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