| Course title | Biochemistry 1 |
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| Course code | UCH/757 |
| Organizational form of instruction | Lecture + Seminary |
| Level of course | Bachelor |
| Year of study | not specified |
| Frequency of the course | In each academic year, in the winter semester. |
| Semester | Winter |
| Number of ECTS credits | 4 |
| Language of instruction | English |
| Status of course | Compulsory |
| Form of instruction | unspecified |
| Work placements | unspecified |
| Recommended optional programme components | None |
| Course availability | The course is available to visiting students |
| Lecturer(s) |
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| Course content |
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1) Composition of organisms, biogenic elements, prokaryotes and eukaryotes - their characterization and composition, organelles and their origin, biological macromolecules, non-covalent interactions, basic concept of metabolism 2) Introduction to metabolism, catabolism, anabolism, oxidation, electron carriers, role of ATP, substrate phosphorylation, high-energy bonds, coenzyme A 3) Respiratory chain, oxidative phosphorylation and photosynthesis 4) Citric acid cycle as a centre of catabolic and anabolic processes in the organism 5) Sugars, classification, structure, function, cyclization, glycosidic bond, polysaccharides, structure and function, glycoconjugates, extracellular matrix. Metabolism of sugars, glycolysis, gluconeogenesis, Pentose phosphate pathways. 6) Lipids, characterization and function, lipids without fatty acids, fatty acids and their role in physicochemical properties of lipids, branched lipids. Lipid metabolism. 7) Biological membranes, composition, function, membrane rafts, membrane transport, signaling, membrane pumps, Na/K concept. 8) Amino acids, structure, properties, function, peptide bond, peptides and proteins, methods of isolation, sequencing, structure determination. 9) Protein structure, Ramachandran plot, primary, secondary, tertiary and quaternary structure. Globular and filamentous proteins, posttranslational modifications. 10) Function of proteins, Hemoglobin, antibodies, actin and myosin, keratin, collagen, fibroin. Metabolism of proteins and amino acids. 11) Nucleic acids, nucleosides and nucleotides, bases, DNA and RNA, structure and function, central dogma, chemical modification of nucleotides 12) Enzymes, function, kinetics, nomenclature, inhibition
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| Learning activities and teaching methods |
Monologic (reading, lecture, briefing), Dialogic (discussion, interview, brainstorming), Work with text (with textbook, with book), Work with multi-media resources (texts, internet, IT technologies)
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| Learning outcomes |
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Course aims at introduction of general biochemistry for students of the Biological Chemistry bachelor study programme. The course provides a broad array of fundamental knowledge of structural and functional biochemistry which are essential for understanding of other subjects in Biological Chemistry curriculum. In the course framework, biochemistry is given as chemistry of non-binding/non-covalent interactions which take place in biological systems on the level of molecules and cells. Structural and functional properties of the components which play a role in the transmission of energy as well as signals are emphasized.
Students know the principles of biochemistry (k1), can describe and explain structures of biomolecules (k2), can apply the gained knowledge in other courses and their research (k3), recognize the structures and structural motifs of biomolecules (k4). |
| Prerequisites |
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Basic knowledge of general, inorganic, organic chemistry and cell biology.
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| Assessment methods and criteria |
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Oral examination
Students must correctly answer at least 50 % questions. |
| Recommended literature |
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| Study plans that include the course |
| Faculty | Study plan (Version) | Category of Branch/Specialization | Recommended semester |
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