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Lecturer(s)
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Čítek Jindřich, prof. Ing. CSc.
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Course content
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Structural genomics, organization and structure of genome. Functional genomics. Comparartive, population genomics, metagenomics. New methods of genome analysis, NGS. Transcriptomics. Maping of genome. Identification and isolation of genes. Gene regulation of important traits. Editation of genome, methods. Regulation of gene expression. Bioinformatics. Genome selection. Microarrays, SNPs. GBLUP-AM. Multi- and one-step aproach. Non-linear genome selection. Imputation. Factors affecting the reliability of GS. Perspectives, whole genome sequencing. Comparation of MAS and GS. GWAS. Metabolomics, nutrigenomics, pharmakogenomics. Supports will be published continuously on the Moodle application.
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Learning activities and teaching methods
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Monologic (reading, lecture, briefing), Dialogic (discussion, interview, brainstorming), Individual preparation for exam, Individual tutoring
- Preparation for classes
- 100 hours per semester
- Preparation for exam
- 100 hours per semester
- Class attendance
- 30 hours per semester
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Learning outcomes
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The goal is to give the students general knowledge on the trends in genomics, molecular genetics, gene and genome analysis of farm animals, gene regulation of economically important traits, and use of genomics in practice.
Knowledge of animal genomics applicable in breeding practice.
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Prerequisites
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Passing of genetics, molecular biology, genomics, population genetics in previous magister study.
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Assessment methods and criteria
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Oral examination
Kowledge of genomics, genome selection and breeding.
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Recommended literature
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Gregory T. R. The Evolution of the Genome. Academic Press, 2004. ISBN 978-0123014634.
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Lesk A. Introduction to Genomics. Oxford University Press, 2017. ISBN 978-0198754831.
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Ruvinsky A., Marshall Graves J. A. (eds.). Mammalian Genomics. CABI Publishing, 2005. ISBN 978-0851999104.
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Samuelsson T. Genomics and Bioinformatics: an Introduction to Programming Tools for Life Scientists. Cambridge University Press, 2012. ISBN 978-1139022095.
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Womack J. E. (ed.). Bovine Genomics. Willey-Blackwell, 2012.
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