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Lecturer(s)
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Bendová Zdeňka, RNDr. Ph.D.
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Course content
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The course deals with the time organization of living organisms, the nature of rhythmic changes at the level of the organism, tissue, cell and biochemical process. Biorhythms of animals and plants, their types and structure. Circadian system, its hierarchy. Suprachiasmatic nuclei (SCN) as the main biological clock of mammals, their localization, rhythmicity in SCN. Molecular-biological basis of circadian rhythmicity: regulation of clock gene transcription and translation. Synchronization of circadian rhythms with a 24-hour day: free running, synchronizers, synchronization mechanism. Photoperiodism of organisms, mechanism of adaptation to photoperiod, significance. Characteristics of melatonin, control of its secretion, function in the circadian system.
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Learning activities and teaching methods
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Monologic (reading, lecture, briefing), Demonstration
- Class attendance
- 12 hours per semester
- Preparation for exam
- 98 hours per semester
- Preparation for classes
- 40 hours per semester
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Learning outcomes
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The course deals with the time organization of living organisms, the nature of rhythmic changes at the level of the organism, tissue, cell and biochemical process. Biorhythms of animals and plants, their types and structure. Circadian system, its hierarchy. Suprachiasmatic nuclei (SCN) as the main biological clock of mammals, their localization, rhythmicity in SCN. Molecular-biological basis of circadian rhythmicity: regulation of clock gene transcription and translation. Synchronization of circadian rhythms with a 24-hour day: free running, synchronizers, synchronization mechanism. Photoperiodism of organisms, mechanism of adaptation to photoperiod, significance. Characteristics of melatonin, control of its secretion, function in the circadian system.
Basic knowledge of chronobiology, especially knowledge of circadian pacemaker morphology and the principle of light synchronization
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Prerequisites
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At least 80% attendance at seminars, 10-15 minute oral presentation, knowledge of basic principles of biological clock function.
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Assessment methods and criteria
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Oral examination
The ability to integrate the principles of time organization of biological processes into the knowledge of basic physiology.
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Recommended literature
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Bell-Pedersen D, Cassone VM, Earnest DJ, Golden SS, Hardin PE, Thomas TL, Zoran MJ. Circadian rhythms from multiple oscillators: lessons from diverse organisms. Nat Rev Genet, 2005.
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Dunlap, J. C. Molecular bases for circadian clocks. Cell, 1999.
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Dunlap JC, Loros JJ, De Coursey. Chronobiology, Sinauer Associates. Inc. Publishers,Sunderland, MA, USA, 2004.
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Hardin PE. The circadian timekeeping system of Drosophila. Curr Biol, 2005.
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Illnerová, H. Chronobiologie. in: Pokroky v neurovědách. UK Praha, 1995.
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Kolář, J. Biologické hodiny rostlin. Academia, Praha, 2006.
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R.G.Foster a L.Kreitzman. Rhythms of Life. Yale University Press,New Haven and London, 2004.
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Sumova A, Bendova Z, Sladek M, Kovacikova Z, Illnerova H. Seasonal molecular timekeeping within the rat circadian clock. Physiol Res., 2004.
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