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Lecturer(s)
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Čítek Jindřich, prof. Ing. CSc.
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Bancroft Ian, prof.
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Course content
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I. Structural and functional genomics. Comparative and population genomics. Metagenomics. Chromosomal genomics. New methods of genome analysis and sequencing. Use of FCM techniques, sorting of chromosomes, NGS. Analysis of genome and transcriptome. II. Genome organization and structure. Mapping, physical and cytogenetic maps. Identification and isolation of genes. Genetic control of important traits. Genome editation, study of gene function. Regulation of gene expression, methods of study. Bioinformatics. III. Genome selection. Microarrays and SNP genotyping. Whole genome sequencing. MAS and GS. GWAS and GEM methods. Associative transcriptomics. Molecular markers. IV. Metabolomics, nutrigenomics, pharmacogenomics.
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Learning activities and teaching methods
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Monologic (reading, lecture, briefing), Work with text (with textbook, with book), Work with multi-media resources (texts, internet, IT technologies), Individual tutoring
- Class attendance
- 28 hours per semester
- Preparation for exam
- 120 hours per semester
- Preparation for credit
- 50 hours per semester
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Learning outcomes
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General knowledge of new trends in genomics and molecular genetics, gene analysis, genome analysis of farm animals, plants and microorganisms. Genetic control of important traits. Practical use of genomics and molecular genetics.
Knowledge of genomics and molecular genetics focused on the practical use in animal and plant breeding.
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Prerequisites
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Knowledge of genetics including population genetics, biochemistry.
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Assessment methods and criteria
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Combined exam
Mastering of the subject with focus on the use in practice. The content will be adjusted according to the thema of doctoral thesis.
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Recommended literature
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Gregory T. R. The Evolution of the Genome. Academic Press, 2004. ISBN 978-0123014634.
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Lesk A. Introduction to Genomics. Oxford University Press, 2017. ISBN 978-0198754831.
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Ruvinsky A., Marshall Graves J. A. (eds.). Mammalian Genomics. CABI Publishing, 2005. ISBN 978-0851999104.
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Samuelsson T. Genomics and Bioinformatics: an Introduction to Programming Tools for Life Scientists. Cambridge University Press, 2012. ISBN 978-1139022095.
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Somers D. J. et al. Plant Genomics. Methods and Protocols. Springer, 2009. ISBN 978-1597454278.
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