Lecturer(s)
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Čurn Vladislav, prof. Ing. Ph.D.
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Course content
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1. Structural and functional genomics. Comparative, population genomics. Metagenomics. Chromosome genomics. New methods of genome analysis and sequencing. Use of FCM techniques and chromosome sorting, NGS techniques and procedures. Genome and transcriptome analysis. 2. Organization and structure of the genome. Mendelian and molecular genetics. Identification of gene / trait donors. Genome mapping, physical and cytogenetic mapping. Gene identification and isolation. 3. Methods of genome editing and study of gene function. Regulation of gene expression, methods of gene expression study. Bioinformatics in the study of the genome. 4. Genetic basis of important traits in major agricultural crops. Genomic selection. Molecular marking. Microarrays of technology in SNP genotyping. Perspectives, whole genome sequencing in genomic selection. MAS and GS systems. GWAS and GEM approaches. Associative transcriptomics.
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Learning activities and teaching methods
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Monologic (reading, lecture, briefing)
- Semestral paper
- 60 hours per semester
- Preparation for exam
- 50 hours per semester
- Class attendance
- 56 hours per semester
- Preparation for credit
- 50 hours per semester
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Learning outcomes
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The aim of the course is to provide an overview of modern trends in molecular genetics, analysis of plant genes and genomes, genetic basis of important traits and practical use of genomics and molecular genetics.
Students will be able to orientate in the issues of methods of molecular biology and plant genetics
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Prerequisites
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Standard knowledge of biology and genetics
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Assessment methods and criteria
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Combined exam
Active participation in laboratora training, understanding the curriculum defined for the exam.
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Recommended literature
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Gregory T. The Evolution of the Genome. Academic Press, 2004..
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Lesk A. Introduction to Genomics. Oxford Univ. Press. 2017..
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Ruvinsky A., Marshall Graves J. A. (eds.). Mammalian Genomics. Wallingford, Cambridge, CABI Publishing 2005..
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Samuelsson, Tore. Genomics and bioinformatics: an introduction to programming tools for life scientists. Cambridge:Samuelsson, Tore. Genomics and bioinformatics: an introduction to programming tools for life scientists. Cambridge:Cambridge University Press, 2012..
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Somers D. J. et al. Plant Genomics. Methods and Protocols. Springer. 2009..
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Womack J. E. (ed.). Bovine Genomics. Willey-Blackwell, 2012..
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