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Lecturer(s)
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Bruce Alexander William, prof. Ph.D.
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Sobotka Roman, prof. Ing. Ph.D.
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Doležal Tomáš, doc. Mgr. Ph.D.
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Course content
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Content of lectures: Introduction to biology and definition of life. Evolutionary theory and questions, which the theory raised about heredity and organism diversity. Cell as a basic unit of life. Mendel's genetics, chromosomal theory of inheritance, Thomas Morgan. Cracking genetic code. Central dogma - gene expression. DNA replication. Methods of molecular biology - PCR, genome sequencing, genomic era. Genetic diversity - germline vs. somatic line, mitosis/meiosis. Mutations. Recombination. Gene expression regulation, cell differentiation and epigenetics. Cell behavior during development. Evo-Devo. Experimental biology and model organisms. Modern biology in application.
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Learning activities and teaching methods
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Monologic (reading, lecture, briefing), Dialogic (discussion, interview, brainstorming), Projection
- Class attendance
- 20 hours per semester
- Preparation for exam
- 30 hours per semester
- Preparation for classes
- 10 hours per semester
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Learning outcomes
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The goal of this course is to introduce students of Biological Chemistry program to molecular basis of life and describe the cell as a basic unit of life. Course will build on the historical aspects of discoveries leading to our current knowledge in genetics, molecular and cellular biology and explore the molecular mechanisms behind development and evolution. Most of the course will be built up on genes and their functioning within the context of the cell and the whole organism, ultimately leading to diversity of life and evolution.
Students should be able to understand basic molecular and cellular mechanisms determining cellular behavior and development of the organism.
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Prerequisites
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The course introduces given problems, does not require specific input knowledge.
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Assessment methods and criteria
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Oral examination, Test
Students must achieve at least 50% score in the final multiple choice test.
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Recommended literature
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BioInquiry - Making Connections in Biology. 3rd edition. Nancy Pruitt, Larry S. Underwood. JOHN WILEY & SONS 2006. ISBN: 0-471-47321-9..
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Endless Forms Most Beautiful: The New Science of Evo Devo. Sean B. Carroll. W. W. Norton & Company; Reprint edition 2006..
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John A. Moore. Science as a Way of Knowing: The Foundations of Modern Biology. Harvard University Press, 1999.
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