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Lecturer(s)
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Petříčková Kateřina, Mgr. Ph.D.
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Course content
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The content of lectures: Structure of genomic DNA of prokaryotes, replication, transcription and translation specificities Mutation and suppression - principles, types, techniques Horizontal DNA transfers - conjugation, transduction and transformation, basic terminology, model mechanisms, methodology Genetics of basic cellular processes - cell division, morphological, physiological and metabolic differentiation of prokaryotes, interaction with a host in pathogenesis and symbiosis, inter-cellular signalization (biofilm, quorum sensing) Modern post-omic techniques in bacterial genetics - basic terminology, databases, software, application examples (details attached)
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Learning activities and teaching methods
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Monologic (reading, lecture, briefing)
- Preparation for classes
- 30 hours per semester
- Preparation for exam
- 30 hours per semester
- Class attendance
- 26 hours per semester
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Learning outcomes
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Basics of bacterial genetics with the emphasis on its applications in common molecular biology techniques, bioinformatics and ecology
The student will get knowledge of basic bacterial genetics, genetic and molecular basis of control of cellular processes, and overview of modern techniques of bacterial genetics including examples of bioinformatic processing of -omic data.
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Prerequisites
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Basic understanding of microbiology and genetics.
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Assessment methods and criteria
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Written examination
To pass the exam, the student must score at least 20 points out of 30 from the final examination text.
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Recommended literature
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Dle vývoje v oboru doplněno o recentní články z odborných časopisů (max 5).
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Snyder L., Peters J.E., Henkin T.M., Champness W.: Molecular genetics of bacteria 4th edition, ISBN-13: 978-1555816278 - vybrané kapitoly.
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Yi-Wei Tang Y-W.,Sussman M., Liu D., Poxton I., Schwartzman J.: Molecular medical microbiology, ISBN: 978-0-12-397169-2 - pro genetiku lidských patogenů, jen vybrané kapitoly.
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