Course: Genetics

« Back
Course title Genetics
Course code KMB/240
Organizational form of instruction Lecture
Level of course Bachelor
Year of study not specified
Frequency of the course In each academic year, in the summer semester.
Semester Summer
Number of ECTS credits 5
Language of instruction Czech
Status of course Compulsory, Compulsory-optional
Form of instruction Face-to-face
Work placements This is not an internship
Recommended optional programme components None
Lecturer(s)
  • Zrzavá Magda, RNDr. Ph.D.
Course content
The content of lectures: Genetic information: structure and function of DNA and RNA, gene structure and expression, chromosomes Variability: mutation types and mechanisms of origin, mutagens, DNA reparation Proteins: protein function, allele, homozygote, heterozygote, dominance, recessivity, pleiotropy, penetrance, expressivity Mitosis, meiosis, and cell cycle: cell cycle phases, phases and function of mitosis and meiosis, plant and animal gametogenesis, independent assortment, crossing-over, nondisjunction Genetic analysis: Mendel's work discovery of segregation and combination, Punnett square, branch diagrams, X2 test, pedigrees, allelism test Gene interactions: reciprocal interaction, recessive and dominant epistasis, inhibition, complementarity, compensation, cumulative and non-cumulative duplicity Genetics of quantitative traits: genetic vs. environmental component, variance, heritability, selection response, QWAS, SNP, hybrid vigor Genetic linkage: recombination frequency, map unit, physical vs. genetic map, complete linkage, interference, gene conversion Genetics of sex: environmental vs. genetic sex determination, sex chromosomes, evolution of sex chromosomes, inheritance of Y-haplotypes, SRY, Y- and X-linked traits, sex-influenced and sex-limited traits, dosage compensation, haplodiploidy Genetics of populations: calculation of allelic and genome frequencies, Hardy-Weinberg equilibrium, inbreeding, bottleneck effect, founder effect, selection types, genetic drift, effective population size, dynamic equilibrium Evolution of the genome: C-value paradox, genome structure, mobile elements (types and role in evolution), hybrid dysgenesis, structural and numeric chromosome aberrations and their role in human health, evolution and agriculture, ectopic recombination, gene families, horizontal gene transfer, genome modifications Epigenetics: euchromatin, heterochromatin, histones, histone modifications, DNA methylation, non-coding RNA, genomic imprinting, kinship theory, paramutations Genetics of organelles, bacteria, and viruses: cytoplasmatic inheritance, mitochondrial genome, hereditary diseases of mtDNA, mitochondrial Eve, genetic barcoding, chloroplast DNA, size and organization of bacterial genome, regulation of gene expression, operons, plasmids, conjugation, transformation, bacteriophage genetics

Learning activities and teaching methods
Monologic (reading, lecture, briefing)
  • Preparation for exam - 60 hours per semester
  • Preparation for classes - 60 hours per semester
  • Class attendance - 36 hours per semester
Learning outcomes
Genetics as a science dealing with the heredity and variability of organisms has become an indispensable component of almost all research in biology and medicine. This prominent position has been achieved through the powerful merger of classical and molecular approaches. The goal of the course is to provide students with an explanation of the basic genetic principles. The course should give all participants a rudimentary knowledge in both classical and molecular genetics as well as to convince them that for modern biological research an understanding of genetics is essential.
The student will obtain basic knowledge of genetics and will be able to use it for a better understanding of various every-day genetic topics including critical evaluation of information from media.
Prerequisites
no special requirements

Assessment methods and criteria
Written examination

To pass the exam, the student must score at least 70% of points from the final examination text.
Recommended literature
  • Anthony J. F. Griffiths, Jeffrey H. Miller, David T.Suzuki, Richard C. Lewontin. An Introduction to Genetic Analysis.
  • KOČOVÁ, M. a kol. Návody a úkoly k praktickým cvičením z lékařské biologie a genetiky. Praha: Karolinum, 2000.
  • Snustad, D. P., Simmons, M. J. Genetika. Brno: Masarykova univerzita, 2009, 871 s..


Study plans that include the course
Faculty Study plan (Version) Category of Branch/Specialization Recommended year of study Recommended semester
Faculty: Faculty of Education Study plan (Version): Biology Education (1) Category: Pedagogy, teacher training and social care - Recommended year of study:-, Recommended semester: Summer
Faculty: Faculty of Science Study plan (Version): Biology for future teachers (1) Category: Biology courses 1 Recommended year of study:1, Recommended semester: Summer
Faculty: Faculty of Education Study plan (Version): Biology Education (1) Category: Pedagogy, teacher training and social care - Recommended year of study:-, Recommended semester: Summer
Faculty: Faculty of Science Study plan (Version): Secondary Schools Teacher Training in Biology (1) Category: Pedagogy, teacher training and social care - Recommended year of study:-, Recommended semester: Summer
Faculty: Faculty of Science Study plan (Version): Biology (1) Category: Biology courses 1 Recommended year of study:1, Recommended semester: Summer
Faculty: Faculty of Science Study plan (Version): Biology for future teachers (1) Category: Biology courses 1 Recommended year of study:1, Recommended semester: Summer
Faculty: Faculty of Science Study plan (Version): Secondary Schools Teacher Training in Biology (1) Category: Pedagogy, teacher training and social care - Recommended year of study:-, Recommended semester: Summer
Faculty: Faculty of Science Study plan (Version): Experimental Biology (1) Category: Biology courses - Recommended year of study:-, Recommended semester: Summer
Faculty: Faculty of Science Study plan (Version): Biomedical Laboratory Techniques (1) Category: Biology courses 1 Recommended year of study:1, Recommended semester: Summer