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Lecturer(s)
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Štefka Jan, doc. RNDr. Ph.D.
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Nazarizadeh Dehkordi Masoud
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Course content
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Content of the lectures: History and general concepts of population genetics, from Mendel to genomics. Population variability, measures of diversity, probability mathematics in population genetics. Hardy-Weinberg equilibrium, dominance-recesivity, Snyder's ratios. HW disequilibrium, Linkage disequilibrium. Genetic drift and population structure, small populations, effective population size, Wahlund's effect, Fst. Nonrandom mating, inbreeding, genotype frequencies, inbreeding coefficient and Fst Mutation and migration equilibria. Theory of neutral molecular evolution, neutral vs. slightly deleterious mutations. Selection and its manifestation in populations, mutation-selection equilibrium, infinite sites and infinite alleles models. Quantitative genetics, phenotypic plasticity, heritability and QTL. Microevolution and population genomics, population structure and selection inference using genomic data. Content of practices: practicing population genetic principles and statistics both manually and using various popgen SW (e.g. genepop, R).
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Learning activities and teaching methods
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Monologic (reading, lecture, briefing), Demonstration
- Preparation for classes
- 60 hours per semester
- Class attendance
- 54 hours per semester
- Preparation for credit
- 20 hours per semester
- Preparation for exam
- 40 hours per semester
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Learning outcomes
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The aim of the course is to provide detailed information on the principles of the formation of population genetic structure in human and in free living organisms, on the theory and methods used to infer polymorphism, population structure and genetic equilibrium, and the processes disrupting the equilibria (microevolution).
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Prerequisites
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unspecified
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Assessment methods and criteria
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Test
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Recommended literature
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Hamilton M. B. (2009) Population genetics, 1st ed. Wiley - Blackwell, Chichester, West Sussex, UK..
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Hartl D. L. & Clark A. G. (1997, 2007) Principles of Population Genetics, 3rd, 4th ed. Sinauer Associates, Sunderland, Massachusetts..
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Hedrick P. W. (2005): Genetics of populations, 3rd ed. Jones and Bartlett, Sudbury, Massachusetts..
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Nei M. (2013) Mutation-Driven Evolution, 1st ed. Oxford University Press, Oxford, UK..
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