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Lecturer(s)
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Maaroufi Houda Ouns
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Lin Yu-Hsien
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Žurovec Michal, prof. RNDr. CSc.
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Course content
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1. Introduction to genetics 2. Genetic mapping and novel gene isolation 3. Human gene mapping 4. Human genetic diseases 5. Model organisms and genetics of development 6. D. melanogaster and developmental genetics 7. C. elegans, apoptosis, RNAi 8. Molecular biology of cancer 9. Progress in cancer therapy 10. Gene editing 11. New methods in molecular genetics
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Learning activities and teaching methods
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Monologic (reading, lecture, briefing), Dialogic (discussion, interview, brainstorming)
- Preparation for classes
- 15 hours per semester
- Class attendance
- 25 hours per semester
- Preparation for exam
- 40 hours per semester
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Learning outcomes
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This course will focus on the use of genetic tools in model systems to study developmental processes and human disease. We will discuss the fundamentals of human genetics and model systems such as Drosophila, yeast, the nematode C. elegans, and the mouse, with an emphasis on gaining a basic understanding of the methods of genetic analysis in vivo. The course thus illustrates the basic principles required to understand modern biology.
Students master basic genetics principles, and enhance their problem-solving skills.
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Prerequisites
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basic understanding of cell and molecular biology
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Assessment methods and criteria
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Written examination
To pass the course, a student must obtain at least 60% of points in the final exam.
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Recommended literature
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An Introduction to Genetic Analysis by Anthony J. F. Griffiths, Jeffrey H. Miller, David T.Suzuki, Richard C. Lewontin,.
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THOMPSON & THOMPSON GENETICS IN MEDICINE Robert Nussbaum, Roderick McInnes, Huntington Willard,.
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Robert A Weinberg. The Biology of Cancer. 2013. ISBN 978081534220.
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