Course: Molecular immunology

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Course title Molecular immunology
Course code KME/087E
Organizational form of instruction Lecture
Level of course Master
Year of study not specified
Frequency of the course In academic years starting with an odd year (e.g. 2017/2018), in the summer semester.
Semester Summer
Number of ECTS credits 3
Language of instruction English
Status of course Compulsory-optional
Form of instruction Face-to-face
Work placements This is not an internship
Recommended optional programme components None
Course availability The course is available to visiting students
  • Lieskovská Jaroslava, Mgr. Ph.D.
  • Kopecký Jan, prof. RNDr. CSc.
Course content
1. Overview of basic function of adaptive and innate immunity, immune cells, regulation of immune system. 2. Innate immunity characterization of pathogen associated molecular pattern (PAMPs) and danger associated molecular pattern (DAMPs) as a basic triggers of immune reaction. 3. Receptors involved in recognition of PAMPs-their classification, structure and specificity (TLR, NLR, RLR, CLR), effector mechanisms of innate immunity -phagocytosis, other receptors on cells of innate immunity (scavanger and complement receptors). 4. Receptors on T and B lymphocytes and their activation by antigen, class I and II MHC molecules, presentation of antigenic peptides, effector mechanism of acquired immunity. 5. Classification and features of T lymphocytes, polarization of immune response. 6. Signaling through immune system receptors - general principles of signal transduction. 7. Signaling in innate immunity and inflammation. 8. Antigen receptor signaling, cytokines receptors and their activation. 9. Development of B and T lymphocytes, rearrangement of receptor genes. 10. Adhesive molecules and recirculation of lymphocytes. 11. Design of experiments for study of immune response to infection.

Learning activities and teaching methods
Monologic (reading, lecture, briefing)
  • Preparation for classes - 4 hours per semester
  • Preparation for exam - 50 hours per semester
  • Class attendance - 26 hours per semester
Learning outcomes
This course will introduce molecular mechanisms of innate and adaptive immunity. It will provide an essential grounding for the understanding of the complex cellular interactions of the immune response.
mandatory prerequisite - Immunology KME/2016
Basics of immunology.

Assessment methods and criteria
Oral examination

Short presentation (approx. 10 min) of selected paper with relevant topic. To show knowledge and understanding of content of lectures.
Recommended literature
  • Abbas A.K., Lichtman A.H., Pillai S.: Cellular and Molecular Immunology (8th ed.), Elsevier 2015, 544..
  • Murphy K., Travers p., Walport M.: Janewayś imunology (7th ed.), Garland Science, Taylor & Francis Group, LLC, New York 2008, 887..

Study plans that include the course
Faculty Study plan (Version) Category of Branch/Specialization Recommended year of study Recommended semester
Faculty: Faculty of Science Study plan (Version): Infection Biology (1) Category: Biology courses - Recommended year of study:-, Recommended semester: Summer