Course: Clinical Biochemistry II.

« Back
Course title Clinical Biochemistry II.
Course code KME/722
Organizational form of instruction Lecture + Lesson
Level of course Master
Year of study not specified
Frequency of the course In each academic year, in the winter semester.
Semester Winter
Number of ECTS credits 5
Language of instruction Czech
Status of course Compulsory
Form of instruction unspecified
Work placements unspecified
Recommended optional programme components None
  • Kovář Jan, RNDr. CSc.
  • Brož Pavel, MUDr. Ph.D.
Course content
Content of lectures: Steroid hormones: biochemistry and laboratory diagnostics. Immunoanalytical methods used in endocrinology. Thyroidal and osteologic laboratory diagnostics. Impact of essential trace elements on the organism. Clinical biochemistry and nutritional support - nitrogen balance, biochemical basis for the measurement of body compartments. Enteral and parenteral nutrition, proteosynthesis and proteolysis regulation, impact of hormones and cytokines on energetic and protein metabolism. Clinical biochemistry examinations in intensive care. Biochemical and endocrine changes in elderly. Cancer markers. Pathobiochemistry of atherosclerosis. Metabolic activity and function of endothel, free oxygen radicals, antioxidative mechanisms. Pathogenesis of atherosclerosis.: ideas, role if risk factors. Regulation of metabolism of cholesterol and triglycerides, lipid transport disorders, aterogenic lipoprotein profile. Content of practices: Determination of selected parameters of lipoprotein metabolism. Protocol elaboration. Familiarisation with the basic problems clinical study preparation and design. Discussion.

Learning activities and teaching methods
Monologic (reading, lecture, briefing)
  • Class attendance - 30 hours per semester
  • Preparation for classes - 40 hours per semester
  • Preparation for exam - 50 hours per semester
  • Field trip - 16 hours per semester
Learning outcomes
Introduction into problems of come specialised fields of clinical biochemistry (biochemistry of critical states) and specialised biochemical investigations. Overview of pathobiochemistry of some population disorders (atherosclerosis, diabetes, cancer).
Student knows the basic examinations in clinical laboratory, for example: urine, liver, heart, cerebrospinal fluid examinations. Student has the knowledge in diagnostic of diabetes mellitus, cancer diseases, atherosclerosis, etc.
Benefit is passing the Clinical biochemistry I.

Assessment methods and criteria
Combined exam, Analysis of the qualification work

Credit: semestral work and 5 minutes presentation of the topic Exam: Multichoice test at at least 50%, possibility of oral correction
Recommended literature
  • Češka R. et al.: Cholesterol a ateroskleróza, léčba dyslipidémií. 4. vyd. Praha, Triton 2012.
  • Jabor A. et al.: Vnitřní prostředí. Praha, Grada 2008.
  • Racek J. et al.: Klinická biochemie. 2. vyd. Praha, Galén a Karolinum 2006.
  • Zima T. et al.: Laboratorní diagnostika. 2. vyd. Praha, Galén 2009.

Study plans that include the course
Faculty Study plan (Version) Category of Branch/Specialization Recommended year of study Recommended semester
Faculty: Faculty of Science Study plan (Version): Clinical Biology (1) Category: Biology courses - Recommended year of study:-, Recommended semester: Winter