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Lecturer(s)
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Bártů Iva, RNDr. Ph.D.
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Kvardová Karolína, Mgr.
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Course content
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Content of lectures: 1. Definition of the field of laboratory hematology; blood and blood elements - composition and function of blood; characteristics of hematopoietic organs. 2. Basic laboratory tests, blood analyzers, blood count, KO parameters. 3. Blood formation: KD - structure and storage, transfer of blood cells from marrow, morphology of haematopoiesis. 4. Growth factors; role of extracellular matrix in hematopoiesis. 5. Stem cells: their properties, importance for gene therapy. 6. Erythrocytes: function, physiology and haemolysis; haemoglobin - structure, function, types, synthesis; iron - uptake and regulation in the body. 7. Erythrocytes and its disorders: red cell anomalies, anaemia. 8. Blood groups: AB0, Rh, MNS, etc. - Significance, antigens, antibodies. 9. Granulopoiesis and granulocytes: disorders of function, quantitative disorders of granulocytes, leukemia. 10. Monocytes and macrophages: production of monocytes and macrophages, disorders of function and production of macrophages and monocytes. 11. Lymphocytes: production and function of lymphocytes, disorders of lymphocyte production and function. lymphoproliferative diseases. 12. Platelets: function and physiology, platelet pathology - thrombocytopenia, thrombocytopathies, acquired and congenital platelet disorders, thrombocytosis. 13. Physiology and pathophysiology of blood clotting. 14. Quantitative and qualitative disorders of plasma coagulation. Content of the exercise: 1. Blood processing for haematological examination - preparation of smear, staining. 2. Basic counting of blood elements. 3. Differential blood count. 4. Differential blood count - pathology. 5. Coagulation tests. 6. Blood and haematopoietic organ sampling in laboratory animals.
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Learning activities and teaching methods
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Monologic (reading, lecture, briefing), Demonstration, Laboratory
- Preparation for classes
- 30 hours per semester
- Class attendance
- 56 hours per semester
- Preparation for exam
- 40 hours per semester
- Preparation for credit
- 16 hours per semester
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Learning outcomes
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Presentation of the basis of laboratory haematology and acquiring of basic laboratory skill in this discipline.
Student will orientate in basics of hemathology. Student will understand to terms as haematopoiesis, erythropoiesis, granulopoiesis, lymphopoiesis, monocytopoiesis, thrombopoiesis. Student will learn about properties and functions of particulary blood cells and blood elements. Student will be able to name disorders of these bloods elements and theoretically applicate specific pharmaceutical drugs.
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Prerequisites
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No specific requirements are necessary.
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Assessment methods and criteria
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Combined exam
Passing combined exam - score at least 50% in the written test, answer 2 out of 3 questions in the oral exam At least 80% presence in practicals
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Recommended literature
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A. Sakalová et al.: Hematológia a transfuziológia. Osveta, Martin 1995.
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B. Friedman: Hematologie v praxi. Galén, Praha 1994.
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E. Beutler et al.: William´s Hematology. 5th edition. McGraw-Hill Book Comp., New York 1995.
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J. V. Dacie and S. M. Lewis: Practical Haematology. Churchil Livingstone, Edinburgh 1984.
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Pecka, Miroslav; Bláha, Milan. Praktická hematologie: laboratorní metody. Český Těšín. 2010.
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Pecka, Miroslav. Laboratorní hematologie v přehledu: fyziologie a patofyziologie hemostázy. Český Těšín. 2004.
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Pecka, Miroslav. Laboratorní hematologie v přehledu: fyziologie a patofyziologie krevní buňky. Český Těšín. 2006.
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Penka, Miroslav; Slavíčková, Eva. Hematologie a transfuzní lékařství. Praha. 2011.
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