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Lecturer(s)
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Vondráková Jana, MUDr. Ph.D.
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Course content
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Content of lectures: 1. Laboratory haematology - subject definition. Fundamentals of comparative haematology. 2. Characterization of haematopoietic organs. Haematopoiesis development. Common characteristics of haematopoietic organs. 3. Morphology of erythropoiesis and granulopoiesis. 4. Morphology of lymphopoiesis , monocytopoiesis and trombocytopoiesis. 5. Stem cells: their features, significance for gene therapy, apoptosis. 6. Growth factors. The role of extracellular matrix in haematopoiesis. 7. Erythrocyte and its disorders, anaemia. 8. Granulopoiesis and granulocyte, granulocyte function disorders, quantitative granulocyte disorders, leukaemia. 9. Monocyte and macrophage. Monocyte and macrophage production. Macrophage and monocyte function disorders. Neoplasia of monocyte-macrophage system. Lymphocyte. Lymphocyte function. Lymphocyte production. Lymphocyte production and function disorders. Lymphoproliferative disease. 11. Thrombocyte. Thrombocyte production and origin. Structural physiology of thrombocytes. Thrombocyte function. Adhesion. Aggregation. Degranulation. Thrombocyte disorders. Thrombocytopenia. Thrombocytopenia due to increased loss of thrombocytes. Thrombocytopenia due to decreased production of thrombocytes. Thrombocytopathy. Acquired disorders of thrombocyte function. Inherited disorders of thrombocyte function. Thrombocytosis. Plasmatic coagulation system. Characteristics of coagulation factors. Coagulation reaction. Thromboplastinogenesis. Thrombin production. Fibrinolysis. Plasminogen. Plasminogen activators. Interaction of plasmin with fibrinogen and fibrin. Natural inhibitors of coagulation and fibrinolysis. Plasma coagulation disorders. Haemophilia A and von Willebrand disease. Haemophilia B. Christmas disease. Other functional disorders of factors. Fibrinogen synthesis disorders. Disseminated intravascular coagulation. Haematology in pharmaceutical research. New drugs and testing. Diagnostic procedures. Prediction of undesired effects on haemopoietic system and blood cells. Human trials. Content of practices: Collection of blood and haematopoietic organs from laboratory animals. Morphology and pathology of blood cell from humans and laboratory animals. Morphology of haematopoietic cells. Plasma coagulation.
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Learning activities and teaching methods
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Demonstration, Laboratory
- Preparation for classes
- 30 hours per semester
- Class attendance
- 56 hours per semester
- Preparation for exam
- 40 hours per semester
- Preparation for credit
- 16 hours per semester
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Learning outcomes
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Presentation of the basis of laboratory haematology and acquiring of basic laboratory skill in this discipline.
Student will orientate in basics of hemathology. Student will understand to terms as haematopoiesis, erythropoiesis, granulopoiesis, lymphopoiesis, monocytopoiesis, thrombopoiesis. Student will learn about properties and functions of particulary blood cells and blood elements. Student will be able to name disorders of these bloods elements and theoretically applicate specific pharmaceutical drugs.
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Prerequisites
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No specific requirements are necessary.
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Assessment methods and criteria
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Combined exam
Passing combined exam - score at least 50% in the written test, answer 2 out of 3 questions in the oral exam At least 80% presence in practicals
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Recommended literature
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A. Sakalová et al.: Hematológia a transfuziológia. Osveta, Martin 1995.
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B. Friedman: Hematologie v praxi. Galén, Praha 1994.
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E. Beutler et al.: William´s Hematology. 5th edition. McGraw-Hill Book Comp., New York 1995.
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J. V. Dacie and S. M. Lewis: Practical Haematology. Churchil Livingstone, Edinburgh 1984.
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