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Lecturer(s)
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Course content
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Content of lectures: Subject of Clinical Biochemistry and its position in laboratory medicine. Trends in present clinical biochemistry. Quality management in the laboratory. Problems of metrology, clinical features, laboratory methods, preanalytical, analytical and postanalytical effects. Reference standards of laboratory examinations and their significance. Metabolic sources of exploitable energy, energetics and internal environment relationship. Role of respiratory, circulatory and excretory systems in homeostasis, effect of hormonal and neural regulation in this process. Exploitation of automatic data processing in clinical laboratories. Content of practices: Information about collection systems. Checking of preanalytical phase in the laboratory. Demonstration of automatic analytic systems and the way of operation. Quality control system. Deminstration of measurmnt using various analytical systems, demonstration of cytological examination methods (urine cytology, likvorology).
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Learning activities and teaching methods
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Monologic (reading, lecture, briefing), Excursion
- Class attendance
- 48 hours per semester
- Preparation for exam
- 50 hours per semester
- Preparation for credit
- 30 hours per semester
- Preparation for classes
- 40 hours per semester
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Learning outcomes
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Introduction into the problems of laboratory medicine in the field of clinical biochemistry. Acquaint them in the overview with present possibilities and technologies of routine examination of various parameters of human biological material mainly in terms of metabolism. Teach the students to understand preanalytical, analytical and postanalytical effects on examination results and the necessity of standardisation of laboratory process. In this context explain the fundamentals of methodology and good laboratory praxis. In the specialised part of the course explain the problems of internal environment of microorganism, regulation mechanisms and some metabolic aspects, mainly in the field of pathobiochemistry of the most basic disorders. Lead students to logical thinking looking at basic biochemical processes.
Student will understand the importance of analytical and cytological testing in laboratory.
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Prerequisites
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No specific requirements are necessary.
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Assessment methods and criteria
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Combined exam
Student draw 2 questions from topics, Both theory and basics of instrumental analysis must be encompassed at least for grade 3.
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Recommended literature
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Koolman Jan. Barevný atlas biochemie. Praha Grada, 2012. ISBN 978-80-247-2977-0.
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Murray R.K.. Harperova ilustrovaná biochemie. Praha Galen, 2012. ISBN 978-80-7262-907-7.
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Racek Raidl et al. Klinická Biochemie, Praha 2021. Praha, 2021. ISBN 978-80-7492.
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Zima et al. Laboratorní diagnostika. Praha, 2013. ISBN 9788074920622.
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Zima T. a kol. Laboratorní diagnostika. Praha Galén, 2013. ISBN 978-80-7492-062-2.
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