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Lecturer(s)
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Věchtová Pavlína, RNDr. Ph.D.
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Štěrba Ján, RNDr. Ph.D.
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Kopecký Jan, prof. RNDr. CSc.
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Course content
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Lectures: Introduction into pharmacology (history, basic terminology). Intercellular signalization and its receptors. Mechanisms of drugs action (specific, nonspecific, agonism, antagonism). Factors influencing the effects of drugs, repeated doses, interactions of drugs. Abnormal reactions to drugs. Pharmacokinetics of drugs (application routes, absorption, distribution, elimination, excretion). Epigenetics and pharmacogenetics. Clinical trials. Introduction to xenobiochemistry and metabolism of xenobiotics. Introduction to toxicology. Ecotoxicology. Laboratory: Pharmacogenetics - testing for the presence of wild-type and mutated alleles of enzymes participating in metabolism of drugs and xenobiotics, detection of a mutation in CCR5 receptor. Demonstration of pharmacological effects on tested animals using simulation software. Demonstration of the use of laboratory animals in practice - excursion into an animal facility.
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Learning activities and teaching methods
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Monologic (reading, lecture, briefing), Work with text (with textbook, with book), Laboratory
- Class attendance
- 60 hours per semester
- Preparation for exam
- 12 hours per semester
- Preparation for credit
- 8 hours per semester
- Semestral paper
- 25 hours per semester
- Preparation for classes
- 45 hours per semester
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Learning outcomes
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The students will gain knowledge about the general relationships between the structure and properties of pharmacologically active and toxic substances a dne their effect on the living organism. Modern scientific fields, such as pharmacogenetics or epigenetics, will be described as well.
Basic information in General pharmacology and related sciences as well as in toxicology will be provided.
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Prerequisites
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Knowledge of biochemistry, molecular biology, human physiology.
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Assessment methods and criteria
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Essay, Student performance assessment, Combined exam, Test, Interim evaluation
Active work in practicals Score 60% of the points in the written exam Submission of the term paper
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Recommended literature
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Karlson et al.: Pathobiochemie.
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Prokeš: Úvod do toxikologie.
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Wenke et al.: Farmakologie pro lékaře I, II.
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