Course: Pharmacology and Toxicology

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Course title Pharmacology and Toxicology
Course code KME/748
Organizational form of instruction Lecture + Lesson
Level of course Master
Year of study not specified
Frequency of the course In each academic year, in the winter semester.
Semester Winter
Number of ECTS credits 6
Language of instruction Czech
Status of course Compulsory
Form of instruction Face-to-face
Work placements This is not an internship
Recommended optional programme components None
Lecturer(s)
  • Věchtová Pavlína, RNDr. Ph.D.
  • Štěrba Ján, RNDr. Ph.D.
Course content
Lectures: Introduction into pharmacology (history, basic terminology). Intercellular signalization and its receptors. Mechanisms of drugs action (specific, nonspecific, agonism, antagonism). Factors influencing the effects of drugs, repeated doses, interactions of drugs. Abnormal reactions to drugs. Pharmacokinetics of drugs (application routes, absorption, distribution, elimination, excretion). Epigenetics and pharmacogenetics. Clinical trials. Introduction to xenobiochemistry and metabolism of xenobiotics. Introduction to toxicology. Ecotoxicology. Laboratory: Pharmacogenetics - testing for the presence of wild-type and mutated alleles of enzymes participating in metabolism of drugs and xenobiotics, detection of a mutation in CCR5 receptor. Demonstration of pharmacological effects on tested animals using simulation software. Demonstration of the use of laboratory animals in practice - excursion into an animal facility.

Learning activities and teaching methods
Monologic (reading, lecture, briefing), Work with text (with textbook, with book), Laboratory
  • Class attendance - 60 hours per semester
  • Preparation for exam - 12 hours per semester
  • Preparation for credit - 8 hours per semester
  • Semestral paper - 25 hours per semester
  • Preparation for classes - 45 hours per semester
Learning outcomes
The students will gain knowledge about the general relationships between the structure and properties of pharmacologically active and toxic substances a dne their effect on the living organism. Modern scientific fields, such as pharmacogenetics or epigenetics, will be described as well.
Basic information in General pharmacology and related sciences as well as in toxicology will be provided.
Prerequisites
Knowledge of biochemistry, molecular biology, human physiology.

Assessment methods and criteria
Essay, Student performance assessment, Combined exam, Test, Interim evaluation

Learning the needed information, gaining sufficient points in the tests, active work during the practical, writing an essay.
Recommended literature
  • Karlson et al.: Pathobiochemie.
  • Prokeš: Úvod do toxikologie.
  • Wenke et al.: Farmakologie pro lékaře I, II.


Study plans that include the course
Faculty Study plan (Version) Category of Branch/Specialization Recommended year of study Recommended semester
Faculty: Faculty of Science Study plan (Version): Clinical Biology (1) Category: Biology courses - Recommended year of study:-, Recommended semester: Winter