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Lecturer(s)
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Vácha František, prof. RNDr. Ph.D.
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Course content
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Basic building blocks of a cell. Energetic metabolism. Biological membranes and membrane transport. Regulation of metabolism - Anaerobic and heteroorganotrophic organisms, Photoautotrophic organisms. Relationship between metabolic pathways, nodal points of metabolism. Developmental and comparative aspects of metabolism, alternative metabolic pathways, secondary metabolites, less common fermentation mechanisms, biochemical adaptations in living systems. Biosynthesis and Catabolism of selected biologically active molecules. Physiological biochemistry of animals and plants, common principles and differences, electron transport, redox events, metabolism of nitrogen fixation. Medical biochemistry, molecular, physiological and pathophysiological processes at the level of cells, tissues and organs, metabolic homeostasis, regulatory mechanisms and integral metabolism. Molecular pathology of the cell. Biotransformation and metabolism of xenobiotics.
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Learning activities and teaching methods
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Monologic (reading, lecture, briefing), Dialogic (discussion, interview, brainstorming), Demonstration
- Class attendance
- 26 hours per semester
- Preparation for exam
- 55 hours per semester
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Learning outcomes
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Supplementary more detailed information to the topics of the course UCH 036 for the chemistry students. The biochemistry and its processes from the chemical point of view.
Overview of basic principles and knowledge of biochemistry. Students will acquire broader knowledge of biochemistry on chemical principles. They gain chemical bases of life, biologicaly active substances, their functioning and interaction and on the biochemical processes and metabolic pathways.
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Prerequisites
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Successful completion of the UCH036 Biochemistry course or a similar basic biochemistry course at another university.
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Assessment methods and criteria
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Oral examination, Student performance assessment
Recommended participation on lectures. Continuous study and self study of the subject. Elaboration of a seminar work is required. During the oral examination, student has to show knowledge from both description and dynamic biochemistry. The overall knowledge of all basic metabolic processes will be required.
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Recommended literature
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Bhagavan N. V.:. Medical Biochemistry, Academic Press (2002, 4th edition).
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John W Baynes, Marek H. Dominiczak. Medical Biochemistry (2019, 5th edition). Elsevier Health Sciences. 2019.
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Stryer L.:. Biochemistry, W.H. Freeman & Co. (2015, 8th edition).
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T. Devlin:. Biochemistry with Clinical Correlations, Wiley-Liss (2010, 7th edition).
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