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Lecturer(s)
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Course content
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Contents of lectures: 1.Analytical part: Principles of all analytical techniques used in Clinical Biochemistry, Instrumentation used in these methods. 2.Homeostasis and Nutrition Water and electrolytes, acid base balance, lipids, proteins, general nutrition, trauma, shock, chronobiology. 3.Biochemistry of major organ disorders ; The biochemical consequences of major disorders of the heart, lung, liver, kidney, gut, brain and muscle will be covered, Details of methodology applicable to this module may be covered here eg. diagnostic enzymology. 4.Endocrinology and Cell Biology Biochemical screening and monitoring in Health and Disease: Principles of screening Genetic disorders and related molecular biology, Therapeutic drug monitoring, Drugs of abuse, Toxicology and drug overdose, Neonatal and Pediatric Biochemistry Contents of laboratories: Practical training of the methods covered by the lecture.
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Learning activities and teaching methods
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Monologic (reading, lecture, briefing), Work with text (with textbook, with book)
- Class attendance
- 26 hours per semester
- Field trip
- 10 hours per semester
- Semestral paper
- 10 hours per semester
- Preparation for exam
- 15 hours per semester
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Learning outcomes
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The subject aims at an introduction into Clinical Biochemistry. Modern analytical techniques as well as procedures used to set-up, assess and maintain the quality of laboratory analysis will be review. Background of physiological and pathological processes affecting biochemical investigations and the use of clinical biochemistry results in the diagnosis and management of common medical disorders will be given.
Student orientates in basic clinical biochemistry, which is necessary for daily pratice in clinical biochemistry lab. Student understands to basic pathophysiological mechanisms of diseases. Student knows the importance of determination basic indicated biochemistry parameters in biochemistry lab.
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Prerequisites
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Knowledge of biochemistry, cell biology, molecular biology, basics of animal and human physiology.
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Assessment methods and criteria
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Student performance assessment, Test
For obtaining credit is necessary to prepare an essay on a specific subject. This essay must be presented subsequently. To pass the exam it is needed to obtain at least 60% points in a test.
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Recommended literature
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Dawn B. et al.: Basic Medical Biochemistry: A Clinical Approach; Lippincott Williams & Wilkins.
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Cholesterol a ateroskleróza, léčba hyperlipidémií ? Češka R., 4. vydání. 2012.
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Klinická biochemie ? Racek J., 2. vydání. 2006.
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Laboratorní diagnostika ? Zima T., 3. vydání. 2012.
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Tietz textbook of Clinical biochemistry and molecular diagnostics ? Burtis C.A.. 2012.
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Vnitřní prostředí ? Jabor A.. 2008.
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