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Lecturer(s)
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Course content
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Contents of lectures: 1.Analytical part: Principles of all analytical techniques used in Clinical Biochemistry, Instrumentation used in these methods. 2.Homeostasis and Nutrition Water and electrolytes, acid base balance, lipids, proteins, general nutrition, trauma, shock, chronobiology. 3.Biochemistry of major organ disorders ; The biochemical consequences of major disorders of the heart, lung, liver, kidney, gut, brain and muscle will be covered, Details of methodology applicable to this module may be covered here eg. diagnostic enzymology. 4.Endocrinology and Cell Biology Biochemical screening and monitoring in Health and Disease: Principles of screening Genetic disorders and related molecular biology, Therapeutic drug monitoring, Drugs of abuse, Toxicology and drug overdose, Neonatal and Pediatric Biochemistry
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Learning activities and teaching methods
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Monologic (reading, lecture, briefing), Work with text (with textbook, with book)
- Class attendance
- 26 hours per semester
- Field trip
- 10 hours per semester
- Semestral paper
- 10 hours per semester
- Preparation for exam
- 15 hours per semester
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Learning outcomes
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The subject aims at an introduction into Clinical Biochemistry. Modern analytical techniques as well as procedures used to set-up, assess and maintain the quality of laboratory analysis will be review. Background of physiological and pathological processes affecting biochemical investigations and the use of clinical biochemistry results in the diagnosis and management of common medical disorders will be given.
Student orientates in basic clinical biochemistry, which is necessary for daily practice in the clinical biochemistry lab (k2, k3). Student knows and understands the basic pathophysiological mechanisms of diseases (k1, k2). Students know the importance of determining basic biochemistry parameters in the biochemistry lab (k1, k2). Students can apply and combine the gained knowledge to analyze and evaluate the basic biochemical parameters and propose some needed examinations for a set of basic symptoms (k4, k5, k6).
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Prerequisites
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Knowledge of biochemistry, cell biology, molecular biology, basics of animal and human physiology.
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Assessment methods and criteria
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Student performance assessment, Test
To pass the exam it is needed to obtain at least 50 % points in a test.
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Recommended literature
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Dawn B. et al.: Basic Medical Biochemistry: A Clinical Approach; Lippincott Williams & Wilkins.
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Cholesterol a ateroskleróza, léčba hyperlipidémií ? Češka R., 4. vydání. 2012.
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Klinická biochemie ? Racek J., 2. vydání. 2006.
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Laboratorní diagnostika ? Zima T., 3. vydání. 2012.
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Tietz textbook of Clinical biochemistry and molecular diagnostics ? Burtis C.A.. 2012.
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Vnitřní prostředí ? Jabor A.. 2008.
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