| Course title | Bioactive Surfaces and Plasma Medicine |
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| Course code | UFY/412 |
| Organizational form of instruction | Lecture |
| Level of course | Doctoral |
| Year of study | not specified |
| Frequency of the course | In each academic year, in the summer semester. |
| Semester | Summer |
| Number of ECTS credits | 3 |
| Language of instruction | Czech, English |
| Status of course | Compulsory-optional |
| Form of instruction | Face-to-face |
| Work placements | This is not an internship |
| Recommended optional programme components | None |
| Course availability | The course is available to visiting students |
| Lecturer(s) |
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| Course content |
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1. Hot-topics in biomedicine Summary of hot topics: bio-detection, cell differentiation, antibacterial/antimicrobial properties, controlled release in time and place. 2. Plasma for biomedicine and fabrication of bioactive surfaces Definition of plasma, active particles in discharges, low pressure and atmospheric discharges, discharges for biomedicine, preparation of functional layers, surface functionalization 3. Living organisms I Composition of living organisms - water, ions, simple molecules and metabolites. Biomacromolecules - sugars, lipids, proteins, nucleic acids 4. Living organisms II Structure of the cell - prokaryotic and eukaryotic organisms, organelles and compartments of the cell, multicellular structures, higher organisms, organs and tissues of the human body 5. Life processes Basic processes in living organisms - DNA replication, Central Dogma (transcription and translation), metabolism 6. Defence mechanisms of the human body Innate and acquired immunity, inflammation, blood clotting, surfaces in the human body and their interaction with cells and molecules 7. Nanostructures for (bio)sensors Basic physical principles of detection using nanostructured surfaces: SPR, LSPR, SERS, LMR, RS, MA-LDI, MS,. Examples and practical applications. 8. Osseointegration Surface interaction with living tissue. Adhesion of proteins. Bone cell growth. Growth factors, non-fouling and fouling surfaces, surfaces with functional groups, grafting of biomolecules onto surfaces, use of osseointegrating surfaces in practice. 9. Antibacterial coatings Different approaches to the formation of antibacterial coatings. Antibacterial nanoparticles and their interaction with living organisms. Antibacterial metals and metal ions. Antibacterial properties based on surface energy, topography and chemical composition of the coating. 10. (Nano)materials for theranostics Theranostics as a combination of therapeutic and diagnostic approaches, nanomedicine, nanoparticles as drug carriers, nanogels, particles as nanorobots, nanoparticles for bioimaging and therapeutics, magnetic and plasmonic nanoparticles. 11. Plasma sterilization Sterilization and decontamination properties of plasma, physicochemical erosion, deactivation of pathogens, deactivation of proteins, role of reactive particles, sterilization under atmospheric pressure. 12. Plasma medicine Basic principles, discharges suitable for therapeutic purposes, effect of reactive particles ROS and RNS, conditioned coagulation, cell-plasma interaction.
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| Learning activities and teaching methods |
Monologic (reading, lecture, briefing), Demonstration, Laboratory
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| Learning outcomes |
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The aim is to introduce students to modern research and development in the field of plasma medicine and plasma nanotechnology for the preparation of surfaces used in biomedical applications. The direct interaction of plasmas with living organisms is also covered. An introduction to the biology of living organisms is included in the course, too.
After completing the course, students will be familiar with the latest trends in plasma medicine and will have an overview of topics at the intersection of plasma physics and biology. |
| Prerequisites |
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Recommended are courses Plasma physics and/or Plasma surface nanoengineering.
UFY/426 ----- or ----- UFY/428 |
| Assessment methods and criteria |
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Oral examination
Knowledge and overview in the frame of lectured topics. |
| Recommended literature |
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| Study plans that include the course |
| Faculty | Study plan (Version) | Category of Branch/Specialization | Recommended semester |
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