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Lecturer(s)
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Havránková Renata, Mgr. Ph.D.
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Course content
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Lectures (2 lessons): 1. Spectrum of electromagnetic radiation. 2. Basic characteristics of ionizing radiation. 3. Interaction with the environment, penetration, shading materials. 4. Mechanisms of the effect of ionizing radiation at the physical, chemical and biomolecular levels. 5. Recognition and signalling of damage, DNA repair. 6. Chromosome aberrations and point mutations, biodosimetry. 7. Mechanisms at the cellular level, reproductive cell death, apoptosis. 8. Stochastic and deterministic effects. 9. Acute radiation sickness. 10. Acute local changes, damage to the fetus in utero, late non-neoplastic damage. 11. External contamination with radioactive substances. 12. Internal contamination with radioactive substances. 13. Physical and biological factors affecting the biological effect of radiation. 14. Chemical factors influencing the biological effect of radiation. Seminars (1 lesson): 1. - 2. Basic quantities and units in the field of ionizing radiation. 3. - 4. Sources of ionizing radiation (natural, artificial). 5. - 6. Radioactivity (natural, artificial), types of radioactive transformations. Law of decay. 7. - 8. Basic radiobiological law, radiosensitivity of tissues and organs. 9. - 10. Organization of health care for irradiated and contaminated persons. 11. - 12. Decontamination. Possibilities of eliminating radioactive substances from the body. 13. - 14. Non-ionizing radiation, types, properties, use.
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Learning activities and teaching methods
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unspecified
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Learning outcomes
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The aim of the subject is to clarify the radiobiological nature of various types of external radiation damage and contamination with radioactive substances, to explain the dependence of the biological effect on the type and dose of radiation, on the distribution of the dose over time, the distribution of the dose in the organism and the importance of reparative processes. Attention will be paid to various pathogenetic forms of acute radiation sickness, their periodization in the clinical picture, diagnosis, prophylaxis and treatment. Students will learn about late and genetic consequences of radiation, growth disorders and teratogenic effects of ionizing radiation will be explained to them.
Competence acquired: After completing the course, the student is able to: characterize basic types of ionizing radiation, describe their interactions with the environment, describe the effect of ionizing radiation on the human organism, including factors that can influence the biological effect; characterize exposure routes, describe the fate of radioactive substances in the body.
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Prerequisites
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unspecified
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Assessment methods and criteria
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unspecified
Form of verification method: oral Additional requirements for the student: 85% participation in seminars (one absence possible), any further absences due to serious reasons must be documented
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Recommended literature
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Publikace ICRP 103. Doporučení Mezinárodní komise radiologické ochrany.
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Havránková, Renata; Freitinger Skalická, Zuzana,; Havránek, Jiří,; Zölzer, Friedo,; Kuna, Pavel. Základy radiobiologie. 1. vydání. České Budějovice : Jihočeská univerzita v Českých Budějovicích, Zdravotně sociální fakulta, 2018. ISBN 978-80-7394-696-8.
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Havránková, Renata. Klinická radiobiologie. 1. vydání. Praha : Grada Publishing, 2020. ISBN 978-80-247-4098-0.
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Kolektiv autorů. Výukový program z radiobiologie. .
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PODZIMEK, František. Radiologická fyzika. Aplikace ionizujícího záření.
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ŠINKOROVÁ, Z., NAVRÁTIL, L. Biomedicínská detekce ionizujícího záření.
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