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Lecturer(s)
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Čurn Vladislav, prof. Ing. Ph.D.
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Course content
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Genotoxic substances and mechanism of their effect in spontaneous and induced mutagenesis, carcinogenesis and teratogenesis. Reversals and suppressor mutations. Transposition. DsDNA repair mechanisms. Molecular basis of carcinogenesis. Methods of genetic risk identification.
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Learning activities and teaching methods
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Monologic (reading, lecture, briefing)
- Semestral paper
- 90 hours per semester
- Preparation for classes
- 50 hours per semester
- Preparation for exam
- 50 hours per semester
- Class attendance
- 56 hours per semester
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Learning outcomes
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The aim of the course is to gain knowledge about the genetic risk, the molecular nature of mutagenesis and methods of identification of mutations and evaluation of the genotoxic effect of substances.
The student can independently navigate in the given issue and is able to use the acquired knowledge in their scientific activities or other practice.
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Prerequisites
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The student is familiar with the issues within the scope of university studies and is willing to study independently.
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Assessment methods and criteria
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Oral examination
Standard knowledge of genetics, physiology and biochemistry.
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Recommended literature
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Brown, T. A. Genomes. 2nd e. London, Taylor & Francis 2002, 624 s..
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Griffits, A. J. F. Modern genetic analysis. New York, W. H. Freeman 1999, 449 s..
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Kufe, D. W. a kol. Cancer Medicine. 6th ed. Hamilton, BC Decker Inc. 2003, 150 s..
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Rosypal, S. Úvod do molekulární biologie I. - V. Brno, Rosypal 2002, 1 200 s..
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Watson, J. D. Molekulární biologie genu. Praha, Academia 1997, 757 s..
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