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Vyučující
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Obsah předmětu
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Lectures: 1. What makes good model organism. 2. E.coli and bacterial models 3. Yeasts 4. Synechocystis 5. Dictyostelium 6. Arabidopsis 7. Caenorhabditis 8. Planarians 9. Drosophila 10. Xenopus laevis 11. Zebrafish 12. Mouse 13. Higher mammalian models 14. Tissue cultures and organoids Excursions - selection of three: Arabidopsis thaliana, Drosophila melanogaster, Dictyostelium discoideaum, Amphioxus lanceolatus, Mus musculus, Saccharomyces cerevisiae, Synechocystys sp., Danio rerio , Liver and adipose tissue organoids, Planarians
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Studijní aktivity a metody výuky
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- Účast na výuce
- 58 hodin za semestr
- Domácí příprava na výuku
- 32 hodin za semestr
- Příprava na zkoušku
- 35 hodin za semestr
- Příprava na zápočet
- 25 hodin za semestr
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Výstupy z učení
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The goal of the course is to introduce students to different model organisms, their possibilities and limits. Last but not least, attention will be paid to the ethical aspects of the use of model organisms and alternative model systems. The graduate of the course should have a basic knowledge of the most widely used model organisms, in vitro alternatives, tools for modifying their genome as well as their potential use in both research and biotechnology.
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Předpoklady
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Molecular Biology (KBM/250 or equivalent course from former university), Basic Cell Biology (KMB/023 or equivalent course from former university), Basic methods in molecular biology (KMB/608 or equivalent course from former university).
KMB/250 a zároveň KMB/023 a zároveň KMB/608
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Hodnoticí metody a kritéria
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nespecifikováno
Requirements on student: Credit: Active participation in practicals (max. 3 absences) Exam: Successful completion of the oral examination (min. 50 %).
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Doporučená literatura
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In addition to above mentioned literature, student students will work with current research and review scientific papers..
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Model systems in biology, MIT Press LTD, EAN: 9780262046947, ISBN: 0262046946, ID: 38965320. 2022.
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Refinements to Animal Models for Biomedical Research, Autor: Musk Gabrielle C., ISBN 9783036503325.
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Science without Laws: Model Systems, Cases, Exemplary Narratives, Edited by Angela N. H. Creager; Elizabeth.
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